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《Guizhou Medical Journal》 2010-02
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Effects of sevoflurane preconditioning against cardiopulmonary bypass-induced oxidative stress response of lungs

Zhong Yi,Gao Qong,Ou Wei,et al.Department of Anesthesiology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China  
Objective To observel effects of sevoflurane preconditioning against cardiopulmonary bypass(CBP)-induced oxidative stress response of lungs.Methods 16 patients undergoing the cardiac valve replacement surgery were randomly divided into control group(group C,n=8) and the sevoflurane group(group S,n=8).During the operation,Midazolam,fentanyl,vecuronium were mainline for maintenance of anesthesia.In group S patients inhaled sevoflurane till the end-tidal concentration to 1.3 MAC before CBP,maintained no less than 30 min,then eluted for 15 min.Meanwhile the other patients in group C only inhale pure oxygen.The blood samples were taken from arterial line in 10 min after induction(T1),after 30 min(T2) and 180 min(T3),after vena cava opened.Furthermore the respiratory index(RI,PA-aDO2/PaO2) were calculated according to the blood-gas analysis.Serum malondialdehyde(MDA),superoxide dismutase(SOD) and myeloperoxidase(MPO) were measur before fore chest closure a bit of tissues of lungs coming from the 2 patients in each group were operated pathological studies.Results Compared with T1,Serum MDA,SOD were significantly higher at T2-3 in two groups(P0.05),also MPO were significantly higher at T2(P0.05),RI were significantly higher at T3 in group C(P0.01).Compared with C group,The MDA level were lower at T2,T3(P0.05)and RI were significantly lower at T3 in group S(P0.05).Microscopic examination showed that there were obviously edema formation in alveolar spaces,alveolar structure was destroyed as well,then the severe neutrophil accumulation were both observed in the two groups,so did the red blood cell infiltration in two groups.but the changes were less severe in group S.Conclusion The sevoflurane preconditioning may attenuate CBP-induced the oxidative stress response of lungs.The sevoflurane preconditioning affects the functional protection of lungs against the early injury of lungs which is induced by CBP as well.
【Fund】: 贵州省科技厅项目(E2008-23)
【CateGory Index】: R614.2
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