Effects of Decoction of Radix Morindae Officinalis on HepA Carcinoma in Mice
Feng Zhaoming; Xiao Liuying; Zhang Dan; Chen Qiwen; Li Haoliang; Zhang Hong; Lin Peiying(GuangZhou Institute of Medicine and Health, Guangzhou 510180)
Objective: To observe the effects of decoction of Radix Morindae Officinalis on Hep A carcinoma inmice.Methods Treating Hep A carcinoma xenografed in NIH mice separately with decoction of Radix Morindae Officinalis andcyclophosphamide (CY), then treating the tumor strain with both agents combined, compare the anitumor effects of one agentalone with both agents combined. Results The decoction (45 g/kg'd × 10d) exerted inhibition Hep A tumor, with antitumor ratebeing above 3O% in 3 experiments (P 0.05-0.01 ): combining the decoction and CY had significantly inhibitory action a-gainst Hep A in mice, and superior to CY (12. 5 mg/kg' d) alone. Conclusion the Radix Morindae Officinalis may have antitu-mor effects on Hep A in mice.