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《Guangzhou Medical Journal》 2001-01
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The natural immunity changes in Henoch-Schonlein Purpura:before and after Cimetidine treatment

Zhaogang,Fu Renyi,Yang Chongli,et al.Guangdong provincial corps hospital,Chinese People's Armed Police Forces,Guangzhou 510507  
The object of this study was to evaluate the effects of Cimetidine treatment to natural immunity in Henoch-Schonlein Purpura(HSP) The NK cell in peripheral blood were detected by double marker flow cytemeter(FCM) in addition, the cytotoxic activity of NK cell in peripheral blood were measured before and after Cimetidine Results: Compared with control group, the NK cell popular and cytotoxic activity of NK cell decreased in children with HSP during acute stage After 5 days Cimetidine treatment, cytotoxic activity of NK cell increased There were no significant differences in NK cell popular before and after treatment Conclusion: Cimetidine treatment can increase cytotoxic activity of NK cell This role of Cimetidine did not depends on increasing the NK cell, but also changed the microcircumstances of NK cell
【CateGory Index】: R554.6
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