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《Hainan Medical Journal》 2004-04
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Study on diagnostic value of analyzing CYFRA21-1 combined with CEA in benign and malignant pleural effusions

SHEN Wen-fu,LIAO Gen-yun,YIN Kai-sheng (The People's Hospital of Jianhu,Jiangsu Province 224700,China)  
Objective To evaluate the diagnostic value of CYFRA21-1 combined with CEA measurement in benign and maligant pleural effusions.Methods CYFRA21-1 and CEA levels were measured with radio-immunoassay in the effusion and serum of 82 patients with pleural effusions.Results Effusion and serum concentration of CYFRA21-1 and CEA in with malignant pleural effusions in patients,were significantly higher than those with benign lung dieases(P0.01).In patients with malignant pleural effusions,concentration of CYFRA21-1 and CEA in pleural effusions were significantly higher than that in serum (P0.01).It is more likely malignant pleural effusions when the ratio of CYFRA21-1 in pleural effusions and serum is over 4.5,or,the ratio of CEA is over 1.2.The sensitivity and specificity of CYFRA21-1 for malignant pleural effusions were 60.0%,81.0% in the serum and 92.5%,57.1%,in the pleural effusions.The sensitivity and specificity of CEA for malignant pleural effusions were 55.0%,90.5% in the serum and 75.0%,90.5% in the pleural effusions.The sensitivity and specificity of CYFRA21-1 combined with CEA were 77.5%,78.6% in the serum and 95.0%,85.7% in the pleural effusions.Conclusions CYFRA21-1 combined with CEA measurement might be an useful index in differential diagnoisis of benign and malignant pleural effusions.
【CateGory Index】: R817.4
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