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《Hainan Medical Journal》 2004-05
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The application of testing COX-2 in gastrocolonic tumors

LIU Ji-hong,GAN Ai-hua,XU An-gao (Department of Gastroenerology,Huizhou Municipal Central Hospital,Huizhou,Guangdong 51600,China)  
Objective To explore the difference of expression of cyclooxygenase-2 (COX-2) between gastrocolic tumors and its clinic appliance value.Methods ABC method was applied to detect COX-2 expression in 20 cases of normal gastric mucosa,12 cases of early phase gastric carcinoma,28 cases of progressive gastric carcinoma,12 cases of normal colonic mucosa,30 cases of colonic adenoma,42 cases of colonic carcinoma.Results 1.Positive rate of COX-2 expression was 5%.58.3%,and 64.3% respectively in normal gastric mucosa,early phase gastric carcinoma and progressive gastric carcinoma.The last two was higher apparently than that in normal gastric mucosa (P0.01).2.positive rate of colonic adenoma and colonic carcinoma,was 86.7% and 71.4%,which was apparently higher than that in normal colonic carcinoma,16.7% (P0.01).There's no difference of COX-2 among high,medium and low differentiation of adenocarcinoma.Conclusions COX-2 expressed higher in gastric carcinoma,colonic carcinoma and colonic adenoma,Its expression in colnic carcinoma was related with the histologic subtype.It's of much importance to detect COX-2's expression in the research of gastrocolonic tumors.
【CateGory Index】: R735.2
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 Shi Hai.Xu Jian-ming.Hu Nai-zhong,Xie Hui-jun. Department of Gastroenterology, the First Affiliated Hospital, Anhui Medical University, Hefei 230022,;Expression of Cyclooxygenase-2 and Prognostic Signficance in Human Gastric Carcinoma[J];Chinese Journal of Clinical Gastroenterology;2003-01
2 QIU Dekai, MA Xiong, PENG Yanshen, et al. Shanghai Institute of Digestive Diseases, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China;Significance of cyclooxygenase-2 expression in human primary hepatocellular carcinoma and adjacent nontumorous tissues[J];Chinese Journal of Digestion;2001-03
3 WANG Xingpeng, XU Xuanfu, WANG Bingxian, et al. Department of Gastroen terology, Shanghai First People's Hospital, Shanghai 200080, China;Regulatory effect of cyclooxygenase-2 on the apoptosis of pancreatic adenocarcinoma cells and its possible mechanism[J];Chinese Journal of Digestion;2002-08
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 HUANG Zhi fang, ZHU Miao zhen, HE Ya ni, SHEN Hai ying, ZHANG Jian guo, YANG Ju rong (Department of Nephrology, Research Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China);The expressions of endothelin-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in human glomeruli[J];Acta Academiae Medicinae Militaris Tertiae;2003-11
2 WANG Bu-hai,QIAN Wei,GAO Yuan-jun,SUN Yan,Hou Xiao-huaDepartment of Gastroenterology,Union Hospital Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Silencing Human COX-2 Gene by Construction of Eukaryotic Expression Vector Expressing the Short Hairpin RNA[J];Chinese Journal of Clinical Gastroenterology;2007-02
3 LI Sheng-bao,TONG Qiang1,WU Qing-ming2,ZHANG Wei-guo1,WANG Qiang1,WANG Xiao-hu11 Department of Gastroenterology,Taihe Hospital,Yunyung Medical college,Shiyan hubei 442000,China2 Department of Gastroenterology,Affiliated Hospital,Wuhan University of Science and Technogy,Wuhan hubei 430000,China;The Effect and Mechanism of Cyclooxygase-2 Inhibitor NS-398 on Apoptosis of Esophageal Carcinoma Cell EC 9706[J];Chinese Journal of Clinical Gastroenterology;2008-04
4 JING Da-dao1,LOU Li-hong1,LI En-ling2,LI Ji-kun11.Department of Gastroenterology,Shanghai First People's Hospital,Shanghai JiaotongUniversity,Shanghai 200080,P.R.China2.Shanghai Institute of Digestive Disease,Shanghai 200001,P.R.China;Chemoprophylactic effect of celecoxib on N-Methyl-N'-nitro-N-nitrosoguanidine-induced gastric cancer in rat model[J];Chinese Journal of Cancer Prevention and Treatment;2007-15
5 TANG Wu-bing,YANG Wen,CAO Xiu-huai,YAO Qi,GU Wei-guang,WU Chu-rong,LUO Hai-tao Department of Oncology,Nanhai Hospital,Foshan City.Nanhai Affiliated Hospital of Nan-Fang Medical University.Foshan City 528200,China.;Clinical significance of cycooxygenase-2 in hepatocellular carcinoma after TACE[J];Journal of Modern Oncology;2008-01
6 XIE Chuan gao,WANG Xing peng,DONG Yu wei,et al. The Second Affiliated Hospital of Zhejiang Uiversity,Hangzhou,310009;Effects of the Selective Cyclooxygenase-2 Inhibitor Celebrex on the Expression of VEGF and PGE_2 in Pancreatic Carcinoma PC-3 Cell Lines[J];The Practical Journal of Cancer;2003-02
7 YIN Xinguang, YANG Zhihong, WANG Bo, WANG Guihua, CAO NingzhuThe Second Hospital of Jiaxing city, Jiaxing 314000;Cyclooxygenase-2 expression and biological characteristics, prognosis in gastric carcinoma[J];Journal of Practical Oncology;2006-04
8 LU Yingying, JING Dadao, WANG Xingpeng, WU Kai. Department of Gastroenterology, The First Peoples's Hospital of Shanghai Jiaotong University, Shanghai (200080);Synergistic Inhibitory Effect of Indomethacin and Erlotinib on the Growth of Pancreatic Cancer Cells[J];Chinese Journal of Gastroenterology;2007-04
9 ZHENG Jian,ZHOU Dan,CHEN Hongyi,LIU Tonglin,LI Jian,and LONG Zhiqiang.Department of Surgery,Jiangsu Provincial Corps Hospital,Chinese People's Armed Police Forces.Yangzhou 225003,China;Inhibitory effect of a non-steroidal anti-inflammatory drug,celecoxib, on angiogenesis in lung cancer[J];Medical Journal of the Chinese People's Armed Police Forces;2004-09
10 Ji Qing Li,Zhen Wang,Zheng Guo,Feng Guo,Zhi Yuan,Fu Cheng Ma,Pei Song Yan Ji Qing Li1,Zhen Wang1,Zheng Guo1,Feng Guo1,Zhi Yuan1,Fu Cheng Ma2,Pei Song Yan2,1Institute of Orthopaedics of PLA,2Department of Pathology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,Shaanxi Rpovince,China;Relationship between the protein expressions of cyclooxygenase-2 and matrix metalloproteinase-7 in high risk osteosarcoma and the related factor of prognosis such as age,gender,onset time[J];Chinese Journal of Clinical Rehabilitation;2004-08
China Proceedings of conference Full-text Database 1 Hits
1 ;NS-398对胰腺癌细胞株PC-3的放射增敏作用及机制研究[A];[C];2009
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 LI Xiaofei , LI Can, ZHANG Wei, GAO Kunxiang, ZHU Yifang, LU Qiang. Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shanxi 710038, P.R.China;Expressions of cyclooxygenase-2 and vascular endothelial growth factor in human lung cancer tissue[J];Chinese Journal of Lung Cancer;2005-02
2 GAO Feng, Feng Yi-zhong, Deng Hai-zhen, et al (Department of Pathology,The Second Hospital Affiliated to Suzhou University,Jiangsu Suzhou 215004,China);The Expression of COX-2 in Pancreatic Carcinoma and Its Clinical Significance[J];Acta Academiae Medicinae Suzhou;2005-03
3 ZHANG Linxi, ZUO Lianfu, QI Fengying*, et al. (Department of Pathology, Hebei Medical University, Shijiazhuang 050017,China);The expressions of COX-2 and p53 gene in esophageal carcinoma and in the carcinogenesis of esophageal epithelia[J];Tumor;2003-02
4 CHENG Shao-Hui,WANG Yang,LEI Jun-Hua.Deparment of Oncology,The Third Hospital,Jilin University,Changchun 130021,China;Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance[J];Chinese Journal of Immunology;2006-06
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Cui Quancai Chen Jie Gu Changfang Li Dechun Liu Tonghua (Department of Patholog PUMC Hospital, Beijing);Establishment and Characterization of a New Human Pancreatic Adenocarcinoma Cell Line[J];Basic Medical Sciences and Clinics;1992-06
2 LU Hong; GE Zhizheng; LIU Wenzhong; CHEN Xiaoyu; PENG Yanshen; XIAO Shudong. (Shanghai Second Medical University Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai 200001);Expression of Cyclooxygenase-2 Protein in Colon Diseases[J];CHINESE JOURNAL OF GASTROENTEROLOGY;2000-03
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