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《Hainan Medical Journal》 2004-05
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The application of testing COX-2 in gastrocolonic tumors

LIU Ji-hong,GAN Ai-hua,XU An-gao (Department of Gastroenerology,Huizhou Municipal Central Hospital,Huizhou,Guangdong 51600,China)  
Objective To explore the difference of expression of cyclooxygenase-2 (COX-2) between gastrocolic tumors and its clinic appliance value.Methods ABC method was applied to detect COX-2 expression in 20 cases of normal gastric mucosa,12 cases of early phase gastric carcinoma,28 cases of progressive gastric carcinoma,12 cases of normal colonic mucosa,30 cases of colonic adenoma,42 cases of colonic carcinoma.Results 1.Positive rate of COX-2 expression was 5%.58.3%,and 64.3% respectively in normal gastric mucosa,early phase gastric carcinoma and progressive gastric carcinoma.The last two was higher apparently than that in normal gastric mucosa (P0.01).2.positive rate of colonic adenoma and colonic carcinoma,was 86.7% and 71.4%,which was apparently higher than that in normal colonic carcinoma,16.7% (P0.01).There's no difference of COX-2 among high,medium and low differentiation of adenocarcinoma.Conclusions COX-2 expressed higher in gastric carcinoma,colonic carcinoma and colonic adenoma,Its expression in colnic carcinoma was related with the histologic subtype.It's of much importance to detect COX-2's expression in the research of gastrocolonic tumors.
【CateGory Index】: R735.2
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