The influence of anticoagulant therapy in the treatment of sudden deafness
WEI Ming-hui, XIANG Deng, TAN Sui-ping, NIE Guo-hui, LU Yong-tian (Department of Otolaryngology, Shenzhen Second Hospital, Shenzhen 518035, China)
Objective To study the influence of the application of anticoagulants(including Batroxobin (DF-521)and Alprostadil injection) in the treatment of sudden deafness.Methods 118 patients with sudden deafness were divided into 3 groups semi-randomly according to diagnosis sequence and were treated with routine treatment, routine treatment plus Batroxobin and routine treatment plus Alprostadil injection respectively. The routine treatment group served as a control group.Results The overall effective rates of Batroxobin group, Alprostadil injection group and routine group were 87.5%, 85% and 67.4% respectively and the cure rates of the three groups were 43.8%, 37.5% and 21.7%. There were significant differences comparing Batroxobin group or Alprostadil injection group with routine group by means of Ridit analysis(p0.05). The therapeutic effect of Batroxobin group and Alprostadil injection group didn't show significant difference. The overall hearing outcomes of the two groups were roughly equivalent.Conclusions The application of different anticoagulant drugs can improve the therapeutic effect of sudden deafness and is recommended to be used as early as possible.
【CateGory Index】： R764.437