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《Hainan Medical Journal》 2011-12
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Clinical significance and expressions of PPARγ in colorectal cance

LI Hui-yan,XIE Xian-he,HOU Mei.Department of Oncology,the People's Hospital of Hainan Province,Haikou 570311,Hainan,CHINA  
Objective To investigate the significance and expression of peroxisome proliferator activated receptor γ(PPARγ) in colorectal carcinoma.Methods S-P immunohistochemicalstaining were adopted to examine the expression of PPARγ in 43 patients with colorectal carcinoma;to compare with their paired adjacent mucosa and normal mucosa.Results The positive rate of PPARγ protein were significantly higher in colorectal carcinomas(65%) than that in their paired adjacent mucosa(37.2%) and normal mucosa(11.6%).From normal colorectal mucosa,adjacent colorectal mucosa to colorectal carcinoma,expression of PPARγ show an ascending tendency(P0.01).In colorectal carcinoma,expression of PPARγ were related with tumor cell differentiation(P0.01),degree of infiltration(P0.01),lymphatic metastasis(P0.01) and distant metastasis(P0.01).Conclusion Expression of PPARγ protein is up-regulation in colorectal carcinoma and adjacent mucosa which are related with better differentiation,the depth of penetration,node metastasis and distant metastasis.PPARγ perhaps participates in the development of colorectal carcinoma and is a new hopeful target for precaution and treatment of colorectal carcinoma.
【CateGory Index】: R735.3
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