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《Strait Pharmaceutical Journal》 2003-06
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Summarization on the Study of 5α-reductase and its Inhibitors

OU Min rui 1,DAI Xiao fu 1,ZHOU Xun sheng 2,CHEN Zan qiu,XU Xiao ping(1.College of Chemistry and Chemical Engineering; 2. Office of Educational administration, Fuzhou University, Fuzhou, Fujian 350002, China)  
The 5α reductase plays an important role in genesis and development of Benign Prostatic Hyperplasia(BPH), and becomes a key target of drugs in treating BPH Searching inhibitors of 5α-reductase also becomes a hot spot in study and development of treating drugs for BPH. This article summarizes the study of 5α reductase and its inhibitors in nearly twenty years at home and abroad, for the purpose of providing a consult for drug treatment and drug development of BPH.
【Key Words】: BPH 5α reductase Inhibitors Progression
【Fund】: 福州大学本科生科研实践项目资助 ( 0 2 0 62 )
【CateGory Index】: R983
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【Co-references】
Chinese Journal Full-text Database 10 Hits
1 OU Min-rui~1, DAI Xiao-fu~1, XUE Feng-chun~1, ZHANG Yi~2, XU Xiao-ping~1 (1. College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, Fujian 350002, China; 2. Office of Educational Administration, Fuzhou University, Fuzhou, Fujian 350002, China);Analysis on the activity of 5α-reductase using high performance liquid chromatography[J];Journal of Fuzhou University(Natural Sciences Edtion);2004-02
2 CHEN Jie-bo,XU Xiao-ping,OU Min-rui,XIE Jun (College of Chemistry and Chemical Engineering,Fuzhou University,Fuzhou,Fujian 350002,China);Screen steroid 5 alpha-reductase inhibitors in vitro by high performance liquid chromatography[J];Journal of Fuzhou University(Natural Sciences Edtion);2005-05
3 RUI Caixia,YANG Xiaoming Beijing Institute of Radiation Medicine, Beijing, 100850, China;Association of Steroid 5α-reductase with Hormone-associated Tumour[J];Journal of Medical Molecular Biology;2006-04
4 YU Kai(Bioengineer College of Southwest Jiaotong University,Chengdu 610031,China);Inhibition of Pterocarpus indicus Willd extract on 5α-reductase[J];West China Journal of Pharmaceutical Sciences;2007-05
5 WU Xue-yan,MAO Jiang-feng,SHI Yi-fan,DENG Jie-ying (Peiking Union Medical College,department of endocrinology in Peiking Union Hospital,100730,China);Steroid 5α-reductase and 5α-reductase type 2 deficiency[J];Basic & Clinical Medicine;2006-03
6 SUN Zu-yue,WU Jian-hui, TU Zeng-hong, ZHU Yan, ZHONG En-hong (National Laboratory of Contraceptive and Devices Research, Shanghai Institute of Planned Parenthood Research; National Evaluation Centre for the Toxicology of Fertility Regulating Drugs, Shanghai 200032, China. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica , Chinese Academy of Science, Shanghai, Shanghai 200031, China);A Convenient and Rapid Model in vitro to Screen Steroid 5 alpha-reductase Inhibitors[J];Shanghai Laboratory Animal Science;2002-04
7 CUI Yugui,ZHANG Guiyuan Department of Reproductive Endocrinology,National Research Institute for Family Planning,Beijing 100081;The steroid 5a-reductase isozyme activities in foreskin of Chinese adult men[J];JOURNAL OF REPRODUCTIVE MEDICINE;1995-01
8 ZHANG Jian, GAO Xiao ping (Institute of Materia Medica, Diao Pharmaceutical Group, Chengdu 610041,China);Expression and Activity Assay of Human Steroid 5 Alpha-Reductase Type Ⅱ in CHO Cells[J];Pharmaceutical Biotechnology;2004-05
9 LIU Ben~1,CHANG Yi-ling~2,CHEN Ke-li~3(1.Ningbo School of Technology,Zhejiang University,Ningbo 315100,China;2.Zhejiang Pharmaceutical College,Ningbo 315100,Chian;3.Hubei College of Traditional Chinese Medicine,Wuhan 430061,China);Progress in the Study of 5α-Reductases Used as A Target in Natural Medicine Screening[J];Pharmaceutical Biotechnology;2006-06
10 ZHANG Lun(Nanjing Pharmaceutical Factory Co.,Ltd.,Nanjing 210007,China);Market Analysis of 5α-Reductase Inhibitor[J];China Pharmacy;2006-20
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