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《Strait Pharmaceutical Journal》 2006-04
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RP-HPLC Determination of Content of Paracetamol in Paracetamol controlled-release Tablets

ZHU Le-kai,Wu Wei-ming,Bao Shi-hui(The Second Affiliated Hospital of Wenzhou Medical College,Wenzhou,325027;China)  
OBJECTIVE To establish HPLC method for the determination of paracetamol in Paracetamol controlled-release tablets.METHODS Using HYPERSIL ODS-C_(18) column(4.6mm×250mm,5μm),methanol-water(52∶48) as the mobile phase.The flow rate was 1.0mL·min~(-1);detection wavelength was 254 nm.Using the method of standard curve.RESULTS The calibration curve was linear in the range of 2.04μg·mL~(-1)~20.40μg·mL~(-1) for geniposide(r=0.9999).The average recovery was 100.06%,and RSD was 2.30%(n=9).CONCLUSION The method is simplicity,accurate,sensitive,reproducible and is suitable for the content determination of paracetamol in Paracetamol controlled-release tablets.
【Key Words】: HPLC Paracetamol Content
【CateGory Index】: R927.2
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