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《Strait Pharmaceutical Journal》 2008-09
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Primary study on antipyretic,anti-inflammatory actions and acute toxicity of Lonicera similis Hemsl

LIU Hua,ZHANG Li-hong,WANG Hong-ping(Sichuan provincial institute for food and drug control,Chengdu 610036,China)  
OBJECTIVE To primarily evaluate the antipyretic,anti-inflammatory actions and acute toxicity of Lonicera similis Hemsl(LSH) produced in Sichuan.METHODS The antipyretic action of LSH was evaluated in pyretic rabbits.The anti-inflammatory effect of LSH was assessed by inflammatory models including carrageen-induced paw edema in rats and xylene-induced ear edema in mice.The acute toxicity of LSH was determined by oral LD50 in mice.RESULTS LSH reduced significantly the anus temperature of rabbits and inhibited inflammatory reactions in rats and in mice.The oral LD50 of LSH in mice was 68.17 g·kg-1 body weight.CONCLUSION LSH has significant antipyretic and anti-inflammatory actions and low toxicity.
【CateGory Index】: R285
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