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《Strait Pharmaceutical Journal》 2008-12
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Experimental study on hemocytolysis of sasanquasaponin

DENG Yuan-rong,ZHUO Yi-rong,WANG Ling(Fujian Health College,Fuzhou 350101,China)  
OBJECTIVE To study the hemocytolysis of sasanquasaponin and the antihemolytic effect of antioxidants on hemocytolysis.METHODS The hemocytolysis of sasanquasaponin was observed by means of the routine test tube method in vitro(macroscopic observation method)and modified hemolytic test method in vitro(spectrophotometry).RESULTS Hemolytic crisis didn,t occur when the concentration of sasanquasaponin≤0.39×10-4mg·mL-1 and the hemolysis rate 5%.The hemolysis rate in the individual tube of the VitC group was apparently lower than that of the sasanquasaponin +VitC group with the same concentration.The results were in conformity with each other between macroscopic observation and spectrophotometry.CONCLUSION At a lower concentration,sasanquasaponin have no hemocytolysis,but have when the concentration was beyond a certain level,and the hemolysis intensity and concentration appears dose-dependent manner.When we put in antitioxidant VitC firstly and then SQS,the hemolysis rate of the SQS decreases obviously,which restrains the hemocytolysis of SQS to some extent.
【Fund】: 福建省卫生厅青年科研基金项目(编号2006-1-19)
【CateGory Index】: R285
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