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《Strait Pharmaceutical Journal》 2009-09
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Experimental study on Inducing apoptosis effects of the protein of Pinellia pedatisecta Schott on human ovarian cancer cell line SKOV3

GU Hang-zhi,ZHENG Fei-yun,ZHOU Li,WANG Hai-chu(Department of Gynecology and Obstetrics,The First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China)  
OBJECTIVE To investigate the effects of the protein of Pinellia pedatisecta Schott on the proliferation of human ovarian cancer cell line SKOV3 in vitro and to determine whether the protein of Pinellia pedatisecta Schott inhibit the growth of ovarian cancer and its mechanism of action.METHODS CCK-8 was used to detect the effect of the protein of Pinellia pedatisecta Schott on the growth of SKOV3 cells in vitro;using flow cytometry,detected the apoptosis of SKOV3 cells treated with the protein of Pinellia pedatisecta Schott by Anexinn-V.RESULTS The protein of Pinellia pedatisecta Schott had some effect of inhibiting the proliferation and inducing apoptosis of SKOV3 cells,and the mechanism would be further studied.CONCLUSION The protein of pinellia pedatisecta schott had some effect of inhibiting the proliferation and inducing apoptosis of SKOV3 cells,and the mechanism would be further studied.
【Fund】: 浙江省中医药项目(2006Y043)
【CateGory Index】: R737.31
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