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《Strait Pharmaceutical Journal》 2012-10
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The studies on synthesis process of Perindopril

GAO Yi-ping,ZHU Yong,TANG Wei-fang,LU Tao*(Department of Organic Chemistry,China Pharmaceutical University,Nanjing 210009,China)  
OBJECTIVE To adapt to the industrialized production,we improved the process for synthesizing Perindopril erbumine.METHODS Using(2S,3aS,7aS)-octahydroindole-2-carboxylic acid and N-((S)-1-carbethoxy-1-butyl)-(S)-alanine as the raw materials,Perindopril erbumine was synthesized via condensation,catalytic hydrogenation and salification reactions.RESULTS The structure of the product was characterized by IR,H-NMR and MS.Compared with the reported method,the reaction time was shortened,the total yield was increased by 16% and the product purity was increased from 94.26% to 99.51% in the improved synthetic process.CONCLUSION The synthetic process is optimized with simple operation and low cost.The purities are qualified and this method can be applied to industrial manufacture.
【CateGory Index】: TQ463.53
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 YANG Xin-hua(Nanjing Suzhong Pharmaceutical Research Co.,Ltd.,Jiangsu Nanjing 210016,China);Synthesis of Perindopril Erbumine[J];Chemical World;2010-09
2 Mo Xueni,Jiang Hao Guangxi TCL College(Nanning 530001);The Influence on Vascular Structure and Function by Prindopril[J];Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease;2005-09
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 LI Xi, PENG Jian, LU Wu-sheng, MENG Su-rong, ZHANG Yun-kun (Department of Caridology,Department of Ultrasonography, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China);Effects of perindopril on blood pressure and cerebral blood flow in elderly patients with essential hypertension[J];Journal of First Military Medical University;2001-05
2 Tang Jiarong, Liu Zhengxiang, Zhou Qiang, Zhang Jing *, Wu Cuihuan ** , Liang Qianshen (  Department of Cardiology, Tongji Hospital, Department of Neurobiology,  Department of Pathology, Tongji Medical University, Wuhan, 430030;EFFECTS OF PERINDOPRIL ON VASCULAR HYPERTROPHY IN RAT WITH EXPERIMENTAL HYPERTENSION[J];CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY;1999-02
3 Wang Zhonglin Li Yifu Zhou Yuming (Department of Cardiology, The Second Affiliated Hospital, Hunan Medical University, Changsha 410008);EFFECTS OF PERINDOPRIL ON HYPERTENSION, SERUM ANGIOTENSIN I CONVERTING ENZYME ACTIVITY AND URING LEVEL OF N ACETYL BETA D GLUCOSAMINIDASE[J];BULLETIN OF HUNAN MEDICAL UNIVERSITY;1997-03
4 Zou Guangtao  Wang Mingyin  Ma Zhimin et al ( Department of Internal Medicine, Zhoukou Prefecture People′s Hospital, Zhoukou 466000);The effect of perindopril and felodipine extended release tablets on platelet activation and fibrinolytic activity in elderly patients with essential hypertension[J];JOURNAL OF CLINICAL CARDIOLOGY;1999-08
5 Zhang Jiancheng Guang Ruijin Ru Lihong et al (Fujian Provincial Institute of Cardiovascular Disease,Fuzhou 350001);Effect of perindopril on the balance of nitric oxide and endothelin in blood of patients with essential hypertension[J];JOURNAL OF CLINICAL CARDIOLOGY;1999-10
6 ZANG Gui ming SHI Xiang yun YANG Ye, et al (The General Navy Hospital ,Beijing 100037,China);The Change of Pancreatic beta-cell Function and Effect of Ramipril in Essential Hypertension Patients[J];Chinese Journal of Hypertension;2001-04
7 Zeng Chunyu, Liu Guangyao, Wang Xukai, Yang Chengming, Wang Baowen, He Duofen (Daping Hospital, The Third Millitary Medical College, Chongqing);Plasma Neuropeptide Y in Spontaneously Hypertensive Rats and Perindopril Treatment[J];CHINESE JOURNAL OF HYPERTENSION;1997-04
8 Li Longgui,Lin Xianhe,Geng Zhaohua. Department of Cardiology,Xinqiao Hospital,Third Military Medical University,Chongqing(400037);Effects of Perindopril and Spironolactone on Myocardial Collagen Matrix Remodeling in Experimental Hypertensive Rats[J];CHINESE CIRCULATION JOURNAL;1999-06
9 Zeng Chunyu, Liu Guangyao, Wang Xukai, et al. Cardiology Department, the Third Affiliated Hospital of the Third Military Medical University, Chongqing 400042;A study on changes of plasma neuropeptide Y in elderly with systolic hypertension and after perindopril treatment[J];CHINESE JOURNAL OF GERIATRICS;1998-01
10 LIN Jinxiu, CHEN Daguang, WU Kegui. Department of Cardiology, Fujian Institute of Hypertension, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005;Greater reduction of urinary albumin excretion in hypertensive patients with perindopril than nifedipine[J];CHINESE JOURNAL OF INTERNAL MEDICINE;1999-05
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