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《Strait Pharmaceutical Journal》 2015-07
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Preliminary Studies on the Mechanism for Reducing Blood Lipids of Huzhang Jiangzhi Granules in Hyperlipidemic Rats

KONG Xiao-long;GUO Mei-hong;HUANG Xing-zhen;HUANG Xiao-dan;FAN Ying;HUANG Yan;Guangxi Medical University,School of Pharmaceutical Sciences;  
OBJECTIVE To study the mechanism for reducing blood lipids of Huzhang Jiangzhi Granules in hyperlipidemic rats. METHODS The hyperlipidemia was induced by administrating with high fat emulsion,different oral doses of Huzhang Jiangzhi Granules were given to rats. The effect for the drug on SOD,MDA,GSH-Px,enzyme activity of LPL,HL and total lipase,characteristic of hemorheology including whole blood viscosity,whole blood reduced viscosity and plasma viscosity,HCT,ER,IEA,IED were observed. RESULTS The SOD activity were all increased to different degrees in positive control group,middle dose group and high dose group compared with the model group,the activity of MDA were reduced to varying degrees,the difference has statistical significance( P 0. 01,P 0. 05). Likewise,the enzyme activity of LPL,HL and total lipase were all increased to different degrees. The parameters of hemorheology were reduced to arying degrees including whole blood viscosity,whole blood reduced viscosity and plasma viscosity,HCT,ER,IEA,IED. the difference has statistical significance( P 0. 01,P 0. 05). CONCLUSION Huzhang Jiangzhi Granules has significant therapeutic effects for hyperlipidemic rats induced by high-fat emulsion. the effects may be related to improve the body' s antioxidant capacity and resist lipid peroxidation mediated by free radical. regulating enzymes activity of LPL and HL and improve characteristic of hemorheology.
【Fund】: 广西南宁科学研究与技术开发计划项目(201109056C);; 广西研究生创新计划项目资助(YCSZ2014117);; 广西高校大学生创新创业计划项目
【CateGory Index】: R285.5
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