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《Strait Pharmaceutical Journal》 2015-07
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Preliminary Studies on the Mechanism for Reducing Blood Lipids of Huzhang Jiangzhi Granules in Hyperlipidemic Rats

KONG Xiao-long;GUO Mei-hong;HUANG Xing-zhen;HUANG Xiao-dan;FAN Ying;HUANG Yan;Guangxi Medical University,School of Pharmaceutical Sciences;  
OBJECTIVE To study the mechanism for reducing blood lipids of Huzhang Jiangzhi Granules in hyperlipidemic rats. METHODS The hyperlipidemia was induced by administrating with high fat emulsion,different oral doses of Huzhang Jiangzhi Granules were given to rats. The effect for the drug on SOD,MDA,GSH-Px,enzyme activity of LPL,HL and total lipase,characteristic of hemorheology including whole blood viscosity,whole blood reduced viscosity and plasma viscosity,HCT,ER,IEA,IED were observed. RESULTS The SOD activity were all increased to different degrees in positive control group,middle dose group and high dose group compared with the model group,the activity of MDA were reduced to varying degrees,the difference has statistical significance( P 0. 01,P 0. 05). Likewise,the enzyme activity of LPL,HL and total lipase were all increased to different degrees. The parameters of hemorheology were reduced to arying degrees including whole blood viscosity,whole blood reduced viscosity and plasma viscosity,HCT,ER,IEA,IED. the difference has statistical significance( P 0. 01,P 0. 05). CONCLUSION Huzhang Jiangzhi Granules has significant therapeutic effects for hyperlipidemic rats induced by high-fat emulsion. the effects may be related to improve the body' s antioxidant capacity and resist lipid peroxidation mediated by free radical. regulating enzymes activity of LPL and HL and improve characteristic of hemorheology.
【Fund】: 广西南宁科学研究与技术开发计划项目(201109056C);; 广西研究生创新计划项目资助(YCSZ2014117);; 广西高校大学生创新创业计划项目
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 8 Hits
1 Li Xiongying1,Chen Suhong2,Lv Guiyuan1*,et al 1. Zhejiang Chinese Medical University, Hangzhou(310053);2.Wenzhou Medical College;Effect of Hesperidin on Blood Fat and Hemorheology in Hyperlipidemia Rats by Fat Emulsion[J];Journal of Zhejiang Chinese Medical University;2013-03
2 ZHANG Qi,MA Bo,ZHU Ling-ling,DU Yu,CHEN Hui (School of Life Science & Pharmaceutical Engineering,Nanjing University of Technology,Nanjing 210009,China);Mechanism of Ginkgo biloba extracts in regulating blood-lipid on experimental hyperlipidemic rats[J];West China Journal of Pharmaceutical Sciences;2007-06
3 LUO Cheng,ZHOU Da,LU Xiao-xiang*(Biotechnology and Food Science College,Tianjin University of Commerce,Tianjin Key Laboratory Food of Biotechnology,Tianjin 300134,China);Research progress in antioxidant mechanism of natural products[J];Science and Technology of Food Industry;2009-04
4 TAN Pin-xin1,YE Tao1,LIU Xiang-xin2,HE Jian-hua3,*(1.College of Food Science and Technology,Hunan Agricultural University,Changsha 410128,China ;2.College of Veterinary Medicine,Hunan Agricultural University,Changsha 410128,China ;3.College of Animal Science and Technology,Hunan Agricultural University,Changsha 410128,China);Research Advances in Antioxidant Composition of Botanical Extracts and Their Action Mechanisms[J];Food Science;2010-15
5 Guo Ming;Gao Zhuye;Wang Peili;Shi Dazhuo;Cardiovascular Department,Xiyuan Hospital,China Academy of Chinese Medicine Sciences;;A Review of Chinese Medicine Herbs and Formulas for Treating Dyslipidemia[J];World Chinese Medicine;2013-12
6 ZHANG Dong,WU Hai-jun,CHEN Shi-ping,YING Kang,YANG Yu-mei(Dept of Pharmacology,Baotou Medical College,Baotou Neimenggu 014010,China);Comparison of the five models on experimental hyperlipidemia rats[J];Chinese Pharmacological Bulletin;2007-09
7 YUAN Jin,GU Wei-wang (Laboratory Animal Center of Southern Medical University,Guangzhou 510515,China);Application of Hemorheology in Clinical Diagnosis and Disease Treatment[J];Chinese Journal of Comparative Medicine;2007-07
8 MAO jiang-hong,WANG qing-shan,NIU xin-yi,TANG jun-qing(The Second Chinese Medicine Hospital of Guangdong Provincial,1.Laboratory;2.Radiology,Guangdong 510095);Research status of clinical hemorheology[J];Chinese Journal of Birth Health & Heredity;2013-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 XU Jun et al(College of Biological Science and Food Engineering,Nanchang University,Nanchang,Jiangxi 330031);Application of Agrocybe Polysaccharides to Evaluate Lipid Model of Mice[J];Journal of Anhui Agricultural Sciences;2010-29
2 LIU GUO-LONG,YANG MU,ZHANG JU-WEN,et al(Qingdao University Medical College,Qingdao 266021,China);THE RELATIONSHIP BETWEEN ACUTE ISCHEMIC HIND LIMB AND ACCOMPANYING VEIN THROMBOSIS:AN EXPERIMENTAL STUDY IN RABBITS[J];Acta Academiae Medicinae Qingdao Universitatis;2008-03
3 YU ZHU-QIN,LIU ZONG-BAO,GONG SHAO-LAN,et al(Department of Medicine,Songshan Hospital,Qingdao University Medical College,Qingdao 266021,China);EFFECTS OF LAMINARIA JAPONICA ON SERUM LIPID IN RATS WITH EXPERIMENTAL HYPERLIPEMIA[J];Acta Academiae Medicinae Qingdao Universitatis;2010-05
4 XU Xin-ying1,YU Zhu-qin1,SHUAI Li2,GUO Yun-liang1 (1Institute of Cerebrovascular Diseases,Affiliated Hospital of Medical College,Qingdao 266003,China;2School of Chemistry,Chemical Engineering and Environmental Sciences,Qingdao University,Qingdao 266003,China);Regulating effects and mechanism of Laminaria japonica on serum lipid of experimental hyperlipemia rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-02
5 WANG Huitang,HOU Ying,YE Lina,LIU Wei,SUN Ping(College of Life Science,Changchun University of Science and technology,Changchun 130022);Effects of Chinese Magnoliavine Fruits on Experimental Hyperlipemia in Rats[J];Journal of Changchun University of Science and Technology(Natural Science Edition);2009-04
6 HUANG Hu-ping,LIN Zhi-hui,SUN Juan,ZHANG Fu-chun.Department of Gastroenterology,Fujian Provincial Hospital,Fuzhou 350001,China;Establishment and analysis of animal model of hyperlipemia rats with severe acute pancreatitis[J];Fujian Medical Journal;2010-02
7 Sun Yan,Liu Hongtao,Tian Sheng,Peng Jinzhu,Gao Shuang(Beijing Physical Examination Center,Beijing 100077,China);Logistic regression analysis on influential factors of hemorheology indicators in physical examination crowd[J];International Journal of Laboratory Medicine;2012-10
8 XIE Hui-chen1,LIU Fen1,YANG Qiang2(1.Department of Integrated Traditional Chinese and Western Medicine,School of Medical Science, Hubei Nationalities College,Enshi 445000,China;2.Department of Integrated Chinese and Western Medicine,Affiliated Hospital,School of Medical Science,Hubei Nationalities College, Enshi 445000,China);Regulation and inhibition of lipid-lowering mixture on blood lipid and blood flow abnormalities of hyperlipemia rats[J];Journal of Jilin University(Medicine Edition);2012-05
9 HE Quan-lei,MIAO Fang,LI Chun-ling(College of Life Science,Northwest A&F University,Yangling 712100,China);Antioxidant activities in vitro of different polar solvent extracts of Asarum himalaicum[J];Acta Prataculturae Sinica;2012-05
10 HE Dong① WANG Xiao-Yu① CHENG Yu-Gang① LIU Wan-Ling① DING Ji-Cheng② WANG Xiang-Dong① LI Xia① ① School of Medicine,Shandong University,Jinan 250012;② Healtang Biotech Co.,Ltd,Jinan 250100,China;The Effect of D-xylose on Lipid Metabolism of Rats with Hyperlipemia and Its Related Mechanism[J];Chinese Journal of Zoology;2012-06
China Proceedings of conference Full-text Database 3 Hits
1 ZHANG Lan,LI Qing-hua,GE Hong-juan,WEN Wu-lue, (Jilin Medical College,Jilin City,Jilin Province,132013,China);Research on Anti-oxidation of Total Flavonoid Extracts from Calyx physalis in vitro[A];[C];2010
2 ;Expression of JAM-C in pancreas tissues of Hypertriglyceridemic Acute pancreatitis rat[A];[C];2013
3 JIANG Shan;ZHANG Yi;SUN Pei-dong;The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University;;Study on the Polyphenolic Contents and Antioxidant Activities of Extracts From Hesperethusa Crenulata Bark[A];[C];2014
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 LIU Jian-hua et al (College of Animal Husbandry and Veterinary Engineering,Henan Agricultural University,Zhengzhou,Henan 450002);Effects of Extraction Methods on Anthraquinone Components and the Antioxidant Activity in Rhubarb[J];Journal of Anhui Agricultural Sciences;2008-22
2 Chen Yuqing;Xu Xiaolin;Chen Jianpin;Fu Renquan(Department of Respiratory Diseases,Affiliated Hospital of Bengbu Medical College,Anhui 233004);Hemorheological properties in pulmonary tuberculosis[J];ACTA ACADEMIAE MEDICINAE BENGBU;1996-03
3 Mu Xuejiao,Zhang Qiang(Anhui Science and Technology University,college of life science,Fengyang Anhui233100);Progress in Research on Antioxidant Bioactive Peptides from Plant[J];Forest By-Product and Speciality in China;2008-03
4 ~1Shen Shengrong;~1Yang Xianqiang(~1Department of Tea Science,Zhejiang Agricultural University,Hangzhou)~2Zhao Baolu;~2Xin Wenjuan(~2Institute of Biophysics,Chinese Academy of Sciences,Beijing);Scavenging Effects of Tea Polyphenol Compound and(-)-EGCG on Oxygen Free Radicals[J];Journal of Tea Science;1992-01
5 Shen Shengrong 1, Zhao Yufang 1, Zhao Baolu 2 (1 Zhejiang Agricultural University, Hangzhou 310029; 2 Institute of Biophysics,Academica Sinica,Beijing 100101);Inhibiting Effect of Catechins to Free Radicals at the Present of Iron Ion[J];JOURNAL OF TEA SCIENCE;1997-S1
6 YIN Li-ming, SHI Yuan-gang (Department of Nutrition and Food Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China);Effects of garlic and oat and their compounds on lipid level and hemorheology of hyperlipidemic rats[J];Acta Academiae Medicinae Militaris Tertiae;2005-06
7 Yu Zhao~a Qiao Feng Tao~a Rong Ping Zhang~b Chang Xin Zhou~(a,*) Hui Dou~a Shu Yun Shi~a Ye Cheng Xiao~a Lian Li Sun~a Su Zeng~a Ke Xin Huang~c Xiao Dong Zhang~b Xiao Kun Li~(c,*) a Department of Traditional Chinese Medicine and Natural Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China b College of Pharmacy,Kunming College of Medicine,Kunming 650031,China c Pharmacy School of Wenzhou Medical College,Wenzhou 325035,China;Two new compounds from Zingiber officinale[J];中国化学快报(英文版);2007-10
8 YANG Zhi-yun,LIU Zheng The Guilin Engineering and Technical College,Guilin 541004,China;Research progress on antioxidant compositions and evaluation of natural medicine[J];Acta Medicinae Sinica;2005-03
9 HUANG Jinhong, ZHANG Zhonghai, WANG Jinyuan. Xijing Hospital of Fourth Military Medical University, Xi'an 710032;The effect of Xiaoweiling Ⅰcapsule on the hemorheology of chronic atrophic gastritis and precancerous lesions[J];Hebei Journal of Traditional Chinese Medicine;2003-05
10 PAN Qing-zhi( The Hospital of Shaft Bearing Group of Harbin, Harbin 150036, China );Affection of Liquidambaric for Hyperviscosity in Hemorrheology[J];Heilongjiang Medical Journal;2005-09
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