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Biosynthesis of the Avermetins

ZHANG Li ping,CHEN Chuan (College of Life Sciences,Hebei University,Baoding 071002,China)  
The avermetins are a group of closely ralated macrocylic lactones with exceedingly high activity against helminths and anthropods.This paper review the biosyntheticpathway of the avermectins and the organization of the biosynthetic gene cluster which many groups have analysed and cloned.According to the cloned gene cluster,people can use genetical technology to obtain the genetical strains which can produce more potent and non toxical avermectins and its derivatives.An extensive program of chemical modificaton can also be carried out to discover more active avermectins.
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