Metabolic Regulation of Fermentation Processes
CHEN Gang-xin,XIE Hong-guo,YANG Feng-Ke(Chemical Engineering College,Qingdao University of Science &Technology,Qingdao 266042,China)
In the field of industrial fermentation,fermentation microbiologists search for a rare overproducing strain in nature, then further deregulate the microorganism so that it overproduces huge quantities of a commercially important product such as a metabolite or an enzyme. Deregulation is brought about by nutritional as well as classical and molecular genetic manipulations to bypass and/or remove negative regulatory mechanisms and to enhance positive regulatory mechanisms. These mechanisms include induction, nutritional regulation by sources of carbon, nitrogen and phosphorus, and feedback control. The controls and their modification are the subjects of this review.
【CateGory Index】： TQ920.1