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New Method for the Preparation of Indole-3-Pyruvic Acid

WANG Da-hui, WEI Gong-yuan (School of Life Science, Soochow University, Suzhou 215007, China)  
Indole-3-pyruvic acid, an important intermediate in the preparation of tryptophan by the method of "Chemical-Enzyme", was prepared by a new method from indole in this paper. Indole-3-pyruvic acid was synthesized sequentially through formylation, condensation and hydrolysis reactions, and the major conditions for the reactions were optimized. Using triethylamine as catalyst and water as solvent, the yield of condensation product could reach 81. 5% if the optimum reaction conditions of time 2. 5 h, temperature 110℃ and substrate concentration 2 mol ·L-1 were selected. When protected by N2 , and selected component of alkali 5: 1, temperature 110℃ , substrate concentration 0. 5 mol·L-1 and time 2 h, the productivity of the hydrolysis reaction could remain 92%. All these datas gave the possibility to the scaling-up for the production of indole-3-pyruvic acid.
【CateGory Index】: TQ251.3
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Chinese Journal Full-text Database 1 Hits
1 Wang Dahui, Wei Ping, Ouyang Pingkai (College of Life Science and Pharmacy,Nanjing University of Chemical Technology,Nangjing,210009);Advance in Studying on D-Tryptophan[J];Chemical Industry and Engineering Progress;2002-02
Chinese Journal Full-text Database 10 Hits
1 LI Jian-xin, ZHANG Xu-mei, XU Qi-shou(Institute of Radiation Medicine,Academy of Military MedicalSciences,Beijing 100850, China);Physiological and Biochemical Effects of Tryptophan and Its Application[J];Amino Acids & Biotic Resources;2005-03
2 YAO Qin~1,JIN Xia~2,ZONG Yi-qiang~1,QU Shen~11Department of Biochemistry and Molecular Biology of Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430074,China2 Department of Incretion of Tongji Hospital of Tongji Medical Collegeof Huazhong University of Science and Technology,Wuhan 430030,China;Cloning,Expression of glyA Gene Isolated from Two Strains and Enzyme Assay[J];Amino Acids & Biotic Resources;2006-01
3 MA Ai-ling,SUN Cheng-hui,FANG Tao,ZHAO Xin-qi (Beijing Institute of Technology, Beijing100081, China);Kinetics of Synthesis of TADF by Hydrogenolysis Debenzylation of TADB[J];Chinese Journal of Explosives & Propellants;2005-01
4 FU Li LIU Xin-hong XU Chun-yan XUE Chuan-xin (College of Science, Beijing University of Chemical Technology, Beijing 100029,China);Monitoring a process for preparing DL-serine by HPLC[J];Journal of Beijing University of Chemical Technology;2003-04
5 WANG Gang, LUO Yun jun, TAN Hui min (School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing100081, China);Synthesis and Characterization of Poly(Propyleneimine) Dendritic Azo Compound[J];Journal of Beijing Institute of Technology;2001-02
6 Wang Minghui, Li Hexing (Department of Chemistry, Shanghai Normal University, Shanghai 200234) Deng Jingfa (Department of Chemistry, Fudan University, Shanghai 200433);PREPARATION OF ULTRAFINE Co B AMORPHOUS ALLOY CATALYST AND ITS CATALYTIC PERFORMANCE IN HYDROGENATION OF ACETONITRILE[J];CHINESE JOURNAL OF CATALYSIS;1999-05
7 Zuo Donghua; Zhang Zhikun; Cui Zuolin; Dong Lifeng (Research Center of Nanocrystalline Materials, Qingdao Institute of Chemical Technology, Qingdao 266042);CATALYTIC PROPERTIES OF NANO-NICKEL PARTICLES WITH A RARE EARTH THIN SHELL FOR NITROBENZENE HYDROGENATION[J];CHINESE JOURNAL OF CATAL YSIS;1996-02
8 Zhou Zhongxin, Zhang Manzheng (ffubei Research Institute of Chemistry, Wuhan);THE EFFECT OF SUBSTITUENTS ON CATALYTIC HYDROGENATION OF NITRO- COMPOUNDS ON ANION EXCHANGE RESIN-SUPPORTED PALLADIUM CATALYST[J];Journal of Molecular Catalysis;1989-01
9 WANG Lian\|yuan, CHENG Zhen\|xing, DONG Zhong\|chao, ZHENG Ming\|sheng, XUE Yong, CHEN Gui\|xia (Key Laboratory of Military Chemistry, Institute of Chemical Defence, Beijing 102205, China);New Preparation Methods of the Supported Platinum Catalyst for Selective Hydrogenation of Nitrobenzene into p-Aminophenol[J];Journal of Molecular Catalysis (China);2002-05
10 Fang Yanxiong Zhang Weigang Liu Chunying Lin Shaobin Gao Zhihao (Department of Chemical Engineering,Center of Analysis,Guangdong University of Technology,Guangzhou,510090)Yang Jinzong (The State Key Laboratory of Fine Chemical Engineering,Dalian University of Technology,Dalian,116012);The Effect of Solvent on the Synthesis of P-Acetaminophenol[J];Guangdong Chemical Industry;1999-04
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 LIAO Ben-ren~1, HONG Yong-yu~2, CHEN Zhi-ping~2, LIU Bo~2 (1. Shanghai Chemical Reagent Research Institute, Shanghai 200333, China; 2. Department of Chemistry, East China Normal University, Shanghai 200062, China);A Facile Synthesis and Resolution of N-acetyl-tryptophan[J];Chinese Journal of Synthetic Chemistry;2001-01
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