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Research Progress in Formation Mechanism of Microemulsion and Its Applications in Drug Solubility Enhancement

XIE Jing1,ZHANG Ying-qing1,PI Jian-bin2,MI Zhi-yuan1(1.Pharmaceutical Department,College of Bioengineering,Hubei University of Technology,Wuhan 430068,China;2.Wuhan Yaan Pharmaceutical Co.,Ltd.,Wuhan 430074,China)  
The microemulsion systems are widely used for their thermodynamic stability,low viscosity,translucent appearance and low price.In this paper,theories about formation mechanism of microemulsions were introduced,the application proceeding of solubility enhancement for insoluble drugs by the microemulsions in injection,orally and transdermal administration system were reviewed,and the current problems and prospects of microemulsion drug delivery system were analyzed.
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