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《Hubei Agricultural Sciences》 2011-16
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The Effect of GPA on the Liver and Spleen of CCl_4 Induced Liver Injury Mouse

ZHANG Xia1,CHENG Fu-sheng2(1.College of Life Science and Technology,Gansu Agricultural University,Lanzhou 730070,China; 2.Lanzhou Institute of Animal Sciences and Veterinary Pharmaceutics,the Chinese Academy of Agricultural Sciences/Key Laboratory of New Animal Drug Project of Gansu Province,Lanzhou 730050,China)  
5 groups of mice were used to study the pharmacological action of garlic polysaccharide(GPA) on the organisms.Except normal control group,the model control group and other three treating groups were taken carbon tetrachloride(CCl4) by intragastric administration to condstruct liver injury mice model.The mice in three treating groups were treated with GPA at three different concentration of 100、200、400 mg/kg.After seven days,the liver,spleen were taken out for histological observation and compared with the model group and the control group.The results showed that there were oberserved extensively granular and vesicular degeneration on the liver and severe congestion in central venous of the mice in the model group.After treated with GPA,the vesicular degeneration disappeared,granular degeneration decreased,congestion in central venous disappeared and extensive proliferation of lymphocyte occurred in spleen.The results indicated that GPA had protective effect on the liver of CCl4 induced liver injury mice,and could improve the immune function of animal's body.
【Fund】: 甘肃省农业生物技术项目(GNSW-2010-07)
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 6 Hits
1 ZHANG Min (College of Food Science,Southwest Agicultural Uniuersity,Chongqing 400716;Research Progress of Healthy Food to Protect Auxiliarily Chemical Liver Damage[J];四川食品与发酵;2005-01
2 Wenling Wang, Xuesong Huang, Lisha Zeng, Jinzhong Wu (Department of Food Science and Engineering, Jinan University,Guangzhou,China,510632);Advance on the polysaccharide of garlic (Allium sativum L.)[J];广州食品工业科技;2004-04
3 ZHENG Min ,PAN Shi-bin JIANG You-ding ,et al (Department of Pharmacology, Xianning College, Xianning Hubei 437100, China );An Acute Toxicity Testing of the Allium Sativum L Polysaccharide and It's Effect on the Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) in Injured Mice Serum or Liver[J];咸宁学院学报(医学版);2003-02
4 TENG Shu-Bao 1, WANG Sheng-Chun 2, HU Yong-Wu 2, TIAN Wei-Bin 2, ZHAO Hui-Ping 2 1Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China, 2Department of Pharmacy, Xijing Hospital, Fourth Military;Wuling capsule reduces immunological liver injury in mice[J];第四军医大学学报;2000-07
5 Chen Nengyu,Wu Rui,Chen L i,L iu Rong,Zhao L imian,Wang Jing,Tian Minqing ( National L aboratory of Applied Organic Chemistry at L anzhou University,L anzhou 730 0 0 0 );RECENT PROGRESSIN THE RESEARCH OF GARLIC[J];天然产物研究与开发;2000-02
6 Sun Peiyi, Li Reiqin, Sun Yun, et al. Medical College, Yangzhou University (Yangzhou, 225001);Anti Free Radical Effect of Radix Angelicae Sinensis on Experimental Liver Injury in Mice[J];中西医结合肝病杂志;1996-04
Chinese Journal Full-text Database 8 Hits
1 Zhou Yuan;Liao Bing;Wang Xurui;Xiong Qingyang;Dai Zhu;Hubei Cancer Hospital;;Study on the Protective Effect and Mechanism of JXHG Decoction on Alcohol Hepatic Injury in Mice[J];中国药师;2017-06
2 YE Ying;XU Jing;WANG Rui-hai;MIAO Qing;LIU Li-mei;Institute of Basic Theory Research of Traditional Chinese Medicine,China Academy of Chinese Medical Sciences;;Research Progress of Garlic Polysaccharide in Chemical,Process Quality,Pharmacology and Application in Past Decade[J];中国实验方剂学杂志;2017-10
3 Xiaorui Wang;Peng Dong;Lanzhou petrochemical college of vocational technology;;The Development Prospect of Biologcal Producys from Garlic[J];云南化工;2017-05
4 ZHENG Zuo-liang;LI Sheng-qing;ZHONG Yu-ping;ZHAN Ruo-ting;PAN Hua-feng;YAN Yan;YAN Ping;Research Center of Chinese Herbal Resource Science and Engineering,Guangzhou University of Chinese Medicine;School of Chinese Meterla Medica,Guangzhou University of Chinese Medicine;Guangzhou University of Chinese Medicine;;Hepatotoxicity,Nephrotoxicity and Colonic Toxicity in Rats Induced by Rubiae Radix et Rhizoma Ethanol Extract[J];中国实验方剂学杂志;2017-12
5 LI Shuai;HUANG Yufang;AN Zhichao;YE Youliang;Resources and Environmental Sciences, Henan Agricultural University;;Investigation of fertilizer application and present situation on garlic in Qixian[J];中国瓜菜;2017-02
6 YU Jia-xin;DUAN Han-ying;WEN Ming;HUANG Xue-song;Department of Food Science and Engineering,Jinan University;;Characteristics of fructan∶ fructan 1-fructosyltransferase in garlic[J];食品工业科技;2017-10
7 Liu Weiwei;Ye Yuhui;Hu Jun;Nie Suping;He Hui;College of Food Science and Technology,Huazhong Agricultural University,Key Laboratory of Environment Correlative Dietology,Ministry of Education;;Hepatoprotection of Soybean Protein Isolate and 7S,11S Proteins[J];中国粮油学报;2016-11
8 CHEN Zi-xing;XU Ming-jiao;HUANG Xue-song;College of Science and Engineering;;Effects of Processing Parameters on Nutrient and Functional Components of Black Garlic[J];中国食物与营养;2016-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ZHENG Min ,PAN Shi-bin JIANG You-ding ,et al (Department of Pharmacology, Xianning College, Xianning Hubei 437100, China );An Acute Toxicity Testing of the Allium Sativum L Polysaccharide and It's Effect on the Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) in Injured Mice Serum or Liver[J];咸宁学院学报(医学版);2003-02
2 Cai Fei, Chen Jinhe, Wu JiliangDepartment of Pharmacology, School of Medicine, Wuhan University, Wuhan 430071, China;Therapeutic Effect of Garlic Polysaccharide onCoxsackie B_3 Viral Myocarditis in Mice[J];武汉大学学报(医学版);2003-02
3 SUN Dong 1, SUN Yi 2 (1 Henan Wugang Environment Protection Bureau, Wu gang 462500; 2 Biological Department of Henan Xin Yang Teachers College, Xin Yang 464000);Extraction Mechinism of De-smelly Garlicin and Development of De-smelly Garlicin Polysaccharose[J];黑龙江农业科学;2003-02
4 CAI Fei 1,WU Ji liang 1,CHEN Jin he 2 (1.Department of Pharmacy,Xianning College,Xianning Hubei 437100,China, 2.Department of Pharmacology,Medical College of Wuhan University);The Effect of Garlic Polysaccharide on Coxsackie B_3 Viral Myocarditis in Mice[J];咸宁学院学报(医学版);2003-01
5 LI Jian xiang,CHEN Yue jin,ZHANG Yu,et al (Nuclear Medical College of Suzhou University,Suzhou 215007 China);Protective Effect of Catechins against CCl_4-Induced Chronic Hepatic Injury in Rat[J];工业卫生与职业病;2003-01
6 YOU Yu-Hong, LIN Zhi-BinDepartment of Pharmacology, School of Basic Medical Science, Peking University Health Science Center, Beijing 100083, China;Protective effects of Ganoderma lucidum polysaccharides peptide on injury of macrophages induced by reactive oxygen species[J];Acta Pharmacologica Sinica;2002-09
7 TANG Yun-an,LIU Yu-qing,WANG Guo-qin,et al.West China School of Public Health,Sichuan University,Chengdu,610041,Sichuan Province,China.;STUDY ON PROTECTIVE EFFECT OF GANODERMA TEA ON CHEMICAL LIVER INJURY AND ITS MECHANISM.[J];现代预防医学;2002-03
8 WEI Jin-feng,ZENG Xiao-lan,WANG Yu-dong,CHEN Yong-fei(School of Chem.and Chem.Engineering,Xinyang Teachers College,Xinyang 464000,China);Researches on the comprehensive utilization of residues of extracting garlic oil(Ⅱ)──The content and method of the comprehensive utilization of garlic residues[J];信阳师范学院学报(自然科学版);2002-01
9 XU Chun-xuan 1, WEI Jin-feng 1, WEI Hong-guang 2 (1.Xingyang Teachers College,Xinyang 464000,China;2.No.3 People′s Hospital of Xinyang City,Xinyang 464000,China);Researches on Comprehensive Utilization of Residues of Garlic-oil Extraction[J];环境科学与技术;2001-06
10 WEI Jin feng,SHONG Shi ling,YE Xian feng,etc (Dept.of Chem.Engineering,Xinyang Teachers College ,Xinyang 464000,China);Researches on the comprehensive utilization of residues of extracting garlic oil(I)——The significance of the comprensive utilization of garlic residues and its component analysis[J];信阳师范学院学报(自然科学版);2001-01
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