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《Hubei Agricultural Sciences》 2011-16
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The Effect of GPA on the Liver and Spleen of CCl_4 Induced Liver Injury Mouse

ZHANG Xia1,CHENG Fu-sheng2(1.College of Life Science and Technology,Gansu Agricultural University,Lanzhou 730070,China; 2.Lanzhou Institute of Animal Sciences and Veterinary Pharmaceutics,the Chinese Academy of Agricultural Sciences/Key Laboratory of New Animal Drug Project of Gansu Province,Lanzhou 730050,China)  
5 groups of mice were used to study the pharmacological action of garlic polysaccharide(GPA) on the organisms.Except normal control group,the model control group and other three treating groups were taken carbon tetrachloride(CCl4) by intragastric administration to condstruct liver injury mice model.The mice in three treating groups were treated with GPA at three different concentration of 100、200、400 mg/kg.After seven days,the liver,spleen were taken out for histological observation and compared with the model group and the control group.The results showed that there were oberserved extensively granular and vesicular degeneration on the liver and severe congestion in central venous of the mice in the model group.After treated with GPA,the vesicular degeneration disappeared,granular degeneration decreased,congestion in central venous disappeared and extensive proliferation of lymphocyte occurred in spleen.The results indicated that GPA had protective effect on the liver of CCl4 induced liver injury mice,and could improve the immune function of animal's body.
【Fund】: 甘肃省农业生物技术项目(GNSW-2010-07)
【CateGory Index】: R285.5
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