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《Journal of Hubei Medical University》 2003-02
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Therapeutic Effect of Garlic Polysaccharide onCoxsackie B_3 Viral Myocarditis in Mice

Cai Fei, Chen Jinhe, Wu JiliangDepartment of Pharmacology, School of Medicine, Wuhan University, Wuhan 430071, China  
Objective: To investigate the therapeutic effect of Garlic Polysaccharide on experimental mice viral myocarditismodel caused by coxsackievirus B 3(CVB 3). Methods: Viral myocarditis model was created by intraperitoneal inoculation with coxsackievirus B 3 solution and mice were randomly devided into four groups: the normal control group,the model control group,the Garlic Polysaccharide group(GP group) and the Astragalus membranaceus group(AM group).The mice of GP group and AM group were treated by Garlic Polysaccharide and Astragalus membranaceus respectively 1 h after CVB 3 infection.Blood and heart samples were obtained on the 8th day after CVB 3 infection. The survival rate and the myocardial histopathologic changes were observed. The serum cardiac enzyme,the content of MDA,the serum NO level, the GSH Px activity,the virus title of heart and the expression of iNOS were also measured. Results: The survival rate,the GSH Px activity of GP group were higher than those of the model control group.The myocardial damage, the serum cardiac enzyme,the content of MDA,the serum NO level,the virus title of heart and the expression of iNOS of GP group reduced more significantly than those of the model control group. Conclusion: Garlic Polysaccharide may have the therapeutic effect on experimental mice viral myocarditis model caused by CVB 3.
【Fund】: 湖北省教育厅资助课题 ( 2 0 0 1B44 0 0 1)
【CateGory Index】: R542.2
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