Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Hubei Medical University》 2004-04
Add to Favorite Get Latest Update

Expression of Shh and Its Recepters mRNA in the Late Tooth Development of Murine Lower Incisor

Zhang Lu,Sun Zhijun,Wang Zhifeng,et alKey Laboratory for Oral Biomedical Engineering,School of Stomatology,Wuhan University,Wuhan 430079,China  
Objective: To investigate the temporal and spatial expression of Shh and its receptors Ptc1、Ptc2 mRNA in the late tooth development of murine lower incisor and to discuss its role in cyto diff erentiation.Methods: The embryonic mouse mandibles of late incisor development(E18.5~P 1.5 ) were obtained and 5μm serial sections were made. DIG labeling RNA probes of Shh,Ptc1 and Ptc2 were generated by in vitro transcription from Shh、Ptc1、Ptc2 cDNA template. The expression pattern of Shh,Ptc1 and Ptc2 mRNA was analyzed by means of in situ hybridization. Results: The expression pattern of Shh and Ptc2 was similar. In the late tooth development,they were expressed in the inner dental epithelium and stratum intermedium of the incisor labial side. Ptc1 mRNA was expressed in the inner dental epithelium and stratum intermedium as well as the odontoblast. Conclusion: In the late incisor development,Shh might participate in the ameloblast and odontoblast differentiation as a paracrine or autocrine signaling molecule.
【Fund】: 国家自然科学基金资助项目 (3 0 1710 11)
【CateGory Index】: R78
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 CHEN Zhi, ZHANG Lu, WANG Zhi feng, SUN Zhi jun, ZHANG Qi,FAN Bing Key Laboratory for Oral Biomedical Engineering, School of Stomatology, Wuhan University, Wuhan 430079,China;Expression of Shh?Ptc1?Ptc2 mRNA in the cap stage of mouse molar[J];Chinese Journal of Stomatology;2003-02
Chinese Journal Full-text Database 7 Hits
1 LIU Hui, WANG Qiang, ZHU Feng,LUO Ping-ping,LIU Tian-lin,WEI Xiao-ling, WANG Li-li . Department of Operative Dentistry and Endodontics, School of Stomatology, Tongji University, Shanghai 200072,China;Effect of fluorosis on the expression of Shh in rat incisors[J];Beijing Journal of Stomatology;2007-04
2 LIN Minkui1,2,WANG Hailiang1,YAN Fuhua1,2 1.Department of Periodontology,The Affiliated Stomatological Hospital,Fujian Medical University,Fuzhou 350002,China;2.Oral Tissue Engineering Center,Fujian Medical University,Fuzhou 350004,China;Expressions of Axin2,Wnt5a and Shh at Cap Stage during Development of Mouse Molar[J];Journal of Fujian Medical University;2010-05
3 LI Lu,CHEN Zhi,ZHANG LuKey Laboratory of Oral Biomedical Engineering of Ministry of Education,School of Stomatology,Wuhan University,Wuhan 430079,China;Research Advance in Dental Patterning[J];Medical Journal of Wuhan University;2008-06
4 HUA Fang,SUN Wei-bin,GE Jiu-yu. Stomatolgical Hospital Affiliated to Medical School,Nanjing University,Nanjing 210008;Molecular cloning of Shh,Wnt5b and Catnb Specific Gene Fragments from Zebrafish Embryos[J];Journal of Oral Science Research;2009-02
5 LIN Yuan, WU Bu-ling, LU Qun,JI Lan,HAN Hua.School of Stomatology,The Fourth Military Medical University,Xi'an 710032,China;The expression of Shh during rat teeth development[J];Journal of Clinical Stomatology;2004-04
6 LIN Yuan,WU Buling,LU Qun, et al. College of Stomatology,The Fourth Military Medical University,Xi'an 710032;Effects of Sonic hedgehog antisense oligodeoxynucleotide on tooth development in vitro[J];Journal of Modern Stomatology;2007-02
7 ZHANG Lu, HUA Fang, SUN Zhi-jun, ZHANG Qi, FAN Ming-wen, CHEN Zhi. Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School of Stomatology, Wuhan University, Wuhan 430079,ChinaCorresponding author: CHEN Zhi, Email:zhichenmail@hotmail.com, Tel:027-87873849;Gene expression of transcription regulator LMO4 in tooth morphogenesis[J];Chinese Journal of Stomatology;2005-05
Chinese Journal Full-text Database 10 Hits
1 WANG Yu 1, QIAN Feng Lan 2, WANG Ping 1, YANG Ya Ning 1, HAO Jian Jun 1 1Department of Conservative Densitry, School of Stomatology, Fourth Military Medical University, Xi'an 710033, China, 2Department of Clinical Laboratory, Chengdu Political Fire Brigade Hospital, Chengdu 610042, China;Effects of basic fibroblast growth factor on proliferation and differentiation of human periodontal ligament cells in vitro[J];Journal of The Fourth Military Medical University;2003-23
2 WANG Zhen1, LIU Hong-wei1, JIN Yan2, LIU Yuan2, LIU Lan-ning1 1Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 2Department of Oral Histology and Pathology, Stomatological College, Fourth Military Medical University, Xi'an 710032, China;Expression of mineral-associated markers in human dental follicle cells in vitro[J];Journal of First Military Medical University;2005-08
3 Zhang Jian, Tian Weidong, Liu Lei, et al\;College of Stomatology, West China University of Medical Sciences\;;Expression of Bone Morphogenetic Protein (BMP)-2,4 in Mouse Embryonic Tooth During the Bud Stage[J];West China Journal of Stomatology;2001-06
4 SI Xiaohui, LIU Zheng. (Research Institute of Stomatology, The Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China);Bone Induction by Human Periodontal Ligament Fibroblasts Transfected with Bone Morphogenetic Protein 2 Gene[J];West China Journal of Stomatology;2003-05
5 YAN Zheng-bin,TIAN Wei-dong, LIU Lei, HOU Jin-qiu,CHEN Xi-zhe,LI Zhi-yong. (Key. Laboratory of Oral Biomedical Engineering Ministry of Education, Sichuan University, Chengdu 610041, China);Establishment of a Culture System of Chick Embryo for Mouse Tooth Germ Development[J];West China Journal of Stomatology;2004-03
6 GE Shao-hua,YANG Pi-shan,ZHAO Ning,LI Shu.(Dept.of Periodontology,School of Stomatology,Shandong University,Jinan 250012,China);Culture and Phenotype Characteristics of Mouse Dental Follicle Cells[J];West China Journal of Stomatology;2005-05
7 Fan Mingwen, Li Chengzhang, Ling Junqi, et al. Stomatological College, Hubei Metrical University, Wuhan 430070;Experimental study of rabbit reparative dentin formation induced by non-collagenous dentine matrir protein I . An animal experimental observation of reparative dentin formation[J];Journal of Comprehensive Stomatology;1996-02
8 ZHU Qi, FAN Ming-wen, ZHANG Qi, et al. College of Stomatology, Wuhan University, Wuhan,430079 [;Study of Developing Mouse Molar Tooth Germs in vitro.[J];Journal of Comprehensive Stomatology;2000-04
9 JIN Zuo-lin,LIN Zu.School of Stomatology,The Fourth Military Medical University, Xi'an 710032;Cultures and Charaterization of Dental Follicle Cells from Human Molars.[J];Journal of Comprehensive Stomatology;2002-04
10 CHENG Min,LI Xiang-wei,MIAO Lei-ying,et al.Hospital of Stomotology of Jilin University,Changchun 130041;Expression Pattern of OSX Protein in Human Tooth Development.[J];Journal of Oral Science Research;2006-04
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 LIANG Li, LIU Hong-chen, WANG Dong-sheng, E Ling-ling. (Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, China);Effects of MAPK pathways on ET-induced IL-6 expression in periodontal ligament cells[J];Chinese Journal of Prosthodontics;2012-05
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Zhi,FAN Ming-wen,ZHANG Qi,et al.College of Stomatology, Wuhan University,Wuhan 430079;The gene expression of TGF-β1 in early stage of rat reparative dentine formation.[J];Journal of Comprehensive Stomatology;2001-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved