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《Journal of Hubei Medical University》 2005-01
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Role of HO-1/CO in Lipopolysaccharide-induced Acute Lung Injury and the Effect of Sodium Nitroprusside on It

Wang Xiaoyuan, Xia Zhongyuan, Du Daping,et al Department of Anesthesiology, Renmin Hospital, Wuhan University, Wuhan 430060, China  
Objective: To investigate the potential role of HO-1/CO systems in LPS-induced acute lung injury (ALI) in rats and to explore the mechanisms of the protective effect of NO donor sodium nitroprusside (SNP) on ALI. Methods: Models of acute lung injury in rats were established through intratracheal instillation of lipopolysaccharide (LPS). Thirty-two Wistar rats were divided randomly into four groups: the sham control group (S group), the LPS intratracheal instillation group (LPS group), the inducer of HO-1 (hemin) pretreatment group (HM group), and the SNP intratracheal administration group (SNP group). The right lung lobes were harvested 8 h after LPS instillation and the left lung lobe was used for bronchoalveolar lavage. The protein expression of HO-1 was observed by using immunohistochemical technique and assessed through HIPAS-2000 image analysis system semi-quantitatively. The lung wet weight to dry weight ratio (W/D), BALF protein, malondialdehyde (MDA) content and lung histopathological changes were detected respectively. Results: Compared with that in S group, the expression of HO-1 was significantly increased in LPS group (P0.01), but in HM and SNP group, it was much higher than that in LPS group(P0.01 and P0.05, respectively). In LPS group, the W/D, BALF protein, and MDA content were obviously higher than those in S group (P0.01), but they were decreased obviously when pretreated with hemin or administrated of SNP (P0.05 and P0.01, respectively). Under microscope, the histopathologic results revealed that the injury in HM and SNP groups was mild as compared with that in LPS proup. Conclusion: The data suggest that the protective effect of HO-1/CO system may be involved in the pathophysiologic procedure of LPS-induced lung injury, and the effect that NO donor-SNP can ameliorate LPS-induced ALI may be related to the up-regulation of HO-1.
【CateGory Index】: R563
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