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《Journal of Hubei Medical University》 2005-06
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Inhibitory Effects of Cyclooxygenase-2 Specific Inhibitor on Human Osteosarcoma and Breast Cancer Cell Line

Sun Jinghua,Cai Lin,Chen Fangzhou,et alDept.of Orthopaedics,Zhongnan Hospital of Wuhan University,Wuhan 430071,China  
Objective: To compare the effects of two kinds of selective cyclooxygenase-2 inhibitors(celecoxib,rofecoxib) on the growth of human osteosarcoma and breast cancer cell line.Methods: The anti-proliferative effect was measured by MTT assay.Cell cycle and apoptosis were analyzed by flow cytometry.(Results:) Cyclooxygenase-2 specific inhibitor had a growth inhibitory and apoptosis-inducting effect on three kinds of tumor cell.The inhibition effects showed a dose-dependence and time-dependence manner.MTT assay indicated a significant difference between the rofecoxib and celecoxib group.The cells treated with Cyclooxygenase-2 specific inhibitors showed G2/M arrest.Moreover,celecoxib was more inhibitorily higher than rofecoxib.Conclusion: Cyclooxygenase-2 specific inhibitors have significant effect on the growth of two kinds of cell line.Cyclooxygenase-2 specific inhibitors may become one of the important medicines in the treatment and metastasis of tumor.
【CateGory Index】: R738.1;R737.9;
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Liu Yujun,Li Shuzhong,Guo Shufang, et al (Department of Orthopaedics,Hekou Hospital,Dongying 257200);VALUE OF EXPRESSION OF LRP AND BCL-2 IN OSTEOSARCOMA AS PREDICTOR OF CHEMORESISTANCE[J];Journal of Binzhou Medical College;2003-04
2 WU Wei,SHANG Guan-ning,WANG Yu-ming(Bone Soft Tissue Department of Surgery,Liaoning Cancer Hospital,Shenyang 110042,China);Effectiveness of osteosarcoma(report of 40 cases)[J];Journal of Dalian Medical University;2008-01
3 ;A case report of huge chondrosarcoma in maxllia[J];Acta Academiae Medicine Militaris Tertiae;2002-11
4 ;A case report of chondroblastoma of the caput femoris[J];Acta Academiae Medicinae Militaris Tertiae;2003-22
5 Zuoqin Yan. Zhengrong Chen, Guangjian Zhang. Department of Orthopaedic Surgery. Zhongshan Hospital of Fudan University. Shanghai, 200032;Limb Salvage for Malignant Tumors of the Knee[J];Foreign Medical Sciences.Section of Orthopaedics;2003-03
6 XIAO Yanbin, XU Jianbo, YANG Yi, et al. Department of Orthopaedics, The Third Affiliated Hospital of Kunming Medical College, Kunming, 650118, China;The preliminary investigation of operation in conjunction with adjuvant postoperative radiation therapy in the treatment of recurrent pigmented villonodular synovitis[J];Chinese Journal of Bone Tumor and Bone Disease;2004-06
7 YANG Zuozhang, XU Jianbo, XIE Lin, et al. Department of Orthopaedics, Yunnan Province Tumor Hospital, Kungming 650118,China;Clinical features and treatment of primary skeletal lymphoma[J];Chinese Journal of Bone Tumor and Bone Disease;2005-03
8 TANG Changyou,PENG Wuzhi, XIANG Qingguo, et al. Department of Orthopaedics, XIANG-Xi Prefecture Hospital of TCM, Jishou,416000 China;The clinical observation of hereditary multiple exostoses of one pedigree of Tujiazu nation[J];Chinese Journal of Bone Tumor and Bone Disease;2005-05
9 XIAO Yanbin, XU Jianbo, LI Ling, et al. Department of Orthopaedics, the 3rd Affiliated Hospital of Kunming Medical College, Yannan 650118, China;Osteosarcoma of old-age: a report of 5 cases[J];Chinese Journal of Bone Tumor and Bone Disease;2005-05
10 Cai Lei Gao Zifen Huang Xiaoyuan Department of Pathology,Beijing Jishuitan Hospital Beijing 100035,China;Clinicopathology analasis of 15 cases of primary mesenchymal chondrosarcoma in bone and soft tissue[J];Chinese Journal of Bone Tumor and Bone Disease;2005-06
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Zhen 1, HUANG Yao Tian 1, HUANG Lu Yu 1, ZHAO Jin Kang 1, YU Hui Dong 1, LIU Ji Zhong 1, DU Xiao Chuan 2, LI Jing Bang 2, YAN Pei Song 3, WANG Zhi Xiang 4 1Institute of Orthopeadics of Chinese PLA, 2Department of Radi;Characteristics of high-risk osteosarcoma and treatment countermeasure[J];Journal of The Fourth Military Medical University;2002-05
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