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《Journal of Hubei Medical University》 2005-06
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Inhibitory Effects of Cyclooxygenase-2 Specific Inhibitor on Human Osteosarcoma and Breast Cancer Cell Line

Sun Jinghua,Cai Lin,Chen Fangzhou,et alDept.of Orthopaedics,Zhongnan Hospital of Wuhan University,Wuhan 430071,China  
Objective: To compare the effects of two kinds of selective cyclooxygenase-2 inhibitors(celecoxib,rofecoxib) on the growth of human osteosarcoma and breast cancer cell line.Methods: The anti-proliferative effect was measured by MTT assay.Cell cycle and apoptosis were analyzed by flow cytometry.(Results:) Cyclooxygenase-2 specific inhibitor had a growth inhibitory and apoptosis-inducting effect on three kinds of tumor cell.The inhibition effects showed a dose-dependence and time-dependence manner.MTT assay indicated a significant difference between the rofecoxib and celecoxib group.The cells treated with Cyclooxygenase-2 specific inhibitors showed G2/M arrest.Moreover,celecoxib was more inhibitorily higher than rofecoxib.Conclusion: Cyclooxygenase-2 specific inhibitors have significant effect on the growth of two kinds of cell line.Cyclooxygenase-2 specific inhibitors may become one of the important medicines in the treatment and metastasis of tumor.
【CateGory Index】: R738.1;R737.9;
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