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《Medical Journal of Wuhan University》 2007-01
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Inhibitive Effect of Matrine on Adhesion and Migration of SGC7901 Cells

PENG Xiaochun~(1,2),ZHANG Jingwei~(3),WEI Lei~(1),WEN Xianmei~(1),WANG Tingting~(1),ZHANG Lijun~(1),LI Hua~(1)~1Dept.of Pathophysiology,School of Medicine,Wuhan University,Wuhan 430071,China~2Dept.of Pathophysiology,Medical School of Yangtze University,Jingzhou 434000,China~3Dept.of Tumor Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China  
Objective: To explore the inhibitive effect of matrine on adhesion and migration of SGC7901 cells.Methods: Adhesive ratio was detected by adhesion assay and migration rate was measured by wound healing assay.A microchemotaxis chamber,Transwell system,was used to observe the effects of matrine on the migration of SGC7901,and PKA activity was tested by PKA activity assay.Results: After SGC7901 cells were treated with matrine of 5, 50,100,250 and 500 mg/L for 24 hours,adhesive ratios were 78.56%,44.28%,42.48%,39.75% and 31.54% respectively.Compared with that of the 5 mg/L and 500 mg/L groups,the adhesive ratio of 50 mg/L group was significantly different(P0.01),but had no significant difference when compared with the 100 mg/L group and 250 mg/L group(P0.05).After SGC7901 cells were treated with 50 mg/L matrine for 24 hours,the migration rate was markedly reduced(P0.01),and matrine significantly decreased SGC7901 migration across the membrane of the microchemotaxis chamber as compared with those in the control group(P0.01),and PKA activity also was significantly reduced(P0.01).Conclusion: Matrine can inhibit adhesion and migration of SGC7901 cells.
【Fund】: 国家自然科学基金资助项目(编号:30570751)
【CateGory Index】: R735.2
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