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《Medical Journal of Wuhan University》 2008-03
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Progress in Study on Regulator of Aquaporins

CHENG Dongliang,WANG ZhiweiDept.of Thoracic and Cardiovascular Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China  
Aquaporins(AQPs) are a family of integral membrane proteins that selectively transport water.Thirteen mammalian AQPs have been molecularly identified and localized to various epithelial,endothelial and other tissues.Phenotype studies of animals,and in some cases humans with AQPs mutations have demonstrated essential roles for AQPs in mammalian physiology and pathophysiology,including urinary concentrating function,exocrine glandular fluid secretion,brain edema formation,regulation of intracranial and intraocular pressure,skin hydration,fat metabolism,tumor angiogenesis,cell migration and so on.These studies suggest that AQPs regulators may play an important role in some diseases.Potential regulators target for not only new diuretic reagents for various forms of pathological water retention,but also target for novel therapeutic ways of brain edema,inflammatory disease,glaucoma,obesity,and cancer.However,potent AQPs regulators for in vivo application remain to be discovered.
【CateGory Index】: R341
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