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《Medical Journal of Wuhan University》 2008-04
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Protection of P38MAPK Inhibitor SB203580 from Hyperoxia-Induced Lung Injury in New-Born Rats

LUO Liman1,SUN Zhiqiang2,YU Jian1,NIE Guoming1,XU Hongtao1,ZOU Minshu1,TIAN Hao1,YANG Xinfeng11Dept.of Paediatrics,2Dept.of Radiology,Wuhan General Hospital,Guangzhou Military Area Command,P.L.A,Wuhan 430070,China  
Objective: To investigate the mechanism of protection from hyperoxia-induced lung injury in new-born rats by SB203580,a P38 MAPK specific inhibitor. Methods: A total of 160 new-born rats were divided into air control group,hyperoxia-induced lung injury group,hyperoxia-induced lung injury + SB203580 group and hyperoxia-induced lung injury + sodium chloride group randomly.After 12 h,24 h,72 h and 1week,rats were executed respectively.Left lungs at 72 h were harvested to detect the expression of P38 MAPK by Western blot,and right lungs at the 4 time points were harvested to detect the concentrations of malondiadehyde(MDA) and total anti-oxygen capability(TAOC).Results: At 72 h,P38 MAPK was expressed positively in hyperoxia-induced lung injury group and hyperoxia-induced lung injury + sodium chloride group.The concentrations of MDA in the two groups increased time-dependently,and were higher than those in the air control group and hyperoxia-induced lung injury + SB203580 group at the each time point(all P0.01).In the two groups,the TAOC decreased time-dependently and were lower than those in the air control group and hyperoxia-induced lung injury + SB203580 group at the each time point(all P 0.01).Conclusion: Hyperoxia-induced lung injury in new-born rats can be relieved by the treatment of SB203580 through inhibiting the oxidative stress.
【CateGory Index】: R722.1
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