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《Journal of Hebei Medical University》 2008-01
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MORPHOLOGICAL STUDIES OF FEMORAL HEAD NECROSIS MODEL IN RABBITS ESTABLISHED BY IMPROVED FREEZING METHOD WITH LIQUID NITROGEN

WANG Jiang-yong1,WANG Bao-zhi1,CUI Hui-xian1,LIU Chang-an2,BIAN Jiang3 (1.Department of Human Anatomy,the School of Basic Medical Science,Hebei Medical University,Shijiazhuang 050017,China;2.Department of Orthopaedics,Bethune International Peace Hospital,Shijiazhuang050010,China;3.Department of Human Anatomy,Shijiazhuang Medical College,Shijiazhuang 050081,China)  
Objective To investigate the advantage of the establishment of animal model of femoral head necrosis with articular surface collapse,using improved freezing method with liquid nitrogen,and reveal the process of repair and collapse.MethodsThe animal models of femoral head necrosis were established in 10 adult New Zealand rabbits by frozen on weight bearing area of femoral head with liquid nitrogen,and femoral head was not dislocated.The specimens were examined through gross anatomy,X-ray plate and histological observation under light microscope at 3,7 day,2,4,6,8 week respectively.ResultsThe femoral heads occurred necrosis 3 days after treatment,and the repair process appeared 2 weeks after operation.The articular surface of 3 femoral heads appeared collapse 4 weeks after operation.One femoral head presented osteoarthritis-like disorder.ConclusionThe rabbit animal model of femoral head necrosis with articular surface collapse can be established by frozen on bearing-weight area of femoral head with liquid nitrogen but the successful rate is not high enough.
【Fund】: 河北省教育厅博士基金资助项目(No.B2004-125)
【CateGory Index】: R681.8
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