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《Harbin Medical Journal》 2011-01
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New Generation of Angiotensin Converting Enzyme Inhibitors,Fosinopril

GAO Yonggui,YANG Jun,ZHANG Chunjuan(Dongli Hospital of Traditional Chinese Medicine in Tianjin,Tianjin 300300,China)  
Fosinopril is the third generation of containing phosphonate angiotensin converting enzyme inhibitors(ACEI),through specific inhibition of the angiotensin converting enzyme peripheral vascular and organization of peripheral vascular and organization the angiotensin converting enzyme way of blocking angiotensin Ⅱ synthesis,and inhibits enzymes that induced too slowly,promoting peptide degradation of vascular endothelial release shu,step-down effect-acting slowly and gradually increase,the maximum effect in near,sodium salt limited or using diuretics can make the effect-acting quickly and enhancement.Fosinopril blessed with improvement of insulin resistance and lower urinary protein function.In obesity,diabetes,hypertension and kidney organs such as the heart and kidney damage,the primary hypertension patients,Fosinopril can have relatively good curative effect,is especially suitable for the associated with heart failure,myocardial infarction,impaired glucose tolerance,diabetic nephropathy hypertension patients.Its characteristic is less adverse effect,smooth effect,no orthostatic hypotension,etc.
【CateGory Index】: R972
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