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《Hebei Medical Journal》 2010-08
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Study on the changes of Th1/Th2 lymphocytes subgroup in patients with type 1 diabetes mellitus complicated by vascular lesion

CHEN Jie.Department of Endocrinology,The Second Affiliated Hospital of Shandong TCM University,Jinan 250001,China  
Objective To investigate the changes of Th1/Th2 lymphocytes subsets in patients with type 1 diabetes mellitus complicated by vascular lesion by means of the detection of the changes of Th1/Th2 lymphocytes subgroup.Methods The enzyme linked immunosorbent assay was used to determine the levels of TNF-α and IFN-γ in serum secreted by Th1 lymphocytes subgroup and the levels of IL-4 and IL-10 secreted by Th2 lymphocytes subgroup in 15 patients with type 1 diabetes mellitus complicated by vascular lesion,the other 21 patients with type 1 diabetes mellitus and 20 healthy volunteers were taken as controls. Results The serum levels of Th1-type cytokines including TNF-α and IFN-γ in diabetic patients were significantly higher than those of normal controls(P0.01);the levels of serum Th2-type cytokines including IL-4 and IL-10 were significantly lower than those of normal controls (P0.01).The serum levels of Th1-type cytokines including TNF-α and IFN-γ were significantly higher than those of the patients without complications (P0.05),however,Th2-type cytokines including IL-4 and IL-10 in diabetic patients complicated by vascular lesion were significantly lower than those of the patients without complications (P0.05).Conclusion The significant drift changes in Th2/Th1 occurre in Th1/Th2 lymphocytes subsets in patients with type 1 diabetes mellitus complicated by vascular lesion,which provides theoretical basis for the exploration of the pathogenesis and monitoring of the disease.
【CateGory Index】: R587.2
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【References】
Chinese Journal Full-text Database 2 Hits
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【Co-citations】
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1 GAO Jin.The Fenyang Hospital of Shanxi Province,Fenyang 032200,China;Relationship between the glycosylated hemoglobin and platelet parameter in diabetes mellitus with asymptomatic cerebral infarction[J];Journal of Practical Medical Techniques;2010-12
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1 ZHANG Li1,MENG Huang-xin1,ZHAO Hong-shan2,LI Qi-yan1,XU Li1,CHEN Zhi-bin1,SHI Dong1,FENG Xiang-hui1(1.Department of Periodontology,Peking University School and Hospital of Stomatology,Beijing 100081,China;2.Peking University Center for Human Disease Genomics);Correlation study on polymorphisms of vitamin D receptor gene in patients with pe-riodontitis[J];Journal of Peking University(Health Sciences);2010-01
2 LI Cuiling ZHANG Wen Women and Children's Medical Center of Guangzhou,Guangzhou 510120,China;Clinical Research on Insulin Pump Therapy in Children with Type 1 Diabetes[J];China Medicine and Pharmacy;2011-09
3 HUANG Xiao-yan1,CHEN Ji-xiong2,MA Zhi-chao1 (1Department of Pediatrics,Hainan Provincial People′Hospital,Haikou 570311;2 Department of Cadre Health Center,Hainan Provincial People′Hospital,Haikou 570311,China);Blood serum level of 25-hydroxy-vitamin D in patients with initial type 1 diabetes mellitus[J];Journal of Hainan Medical University;2012-04
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1 Sarentuya(The Second Department of VIP Wards,Beijing Chaoyang Diabetes Hospital,Beijing 100025,China);Type 1 Diabetes Mellitus Complicated with Diabetic Ketoacidosis Misdiagnosed as Acute Pancreatitis[J];Clinical Misdiagnosis & Mistherapy;2013-08
【Secondary Citations】
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1 Yan Sunjie, Zhuo Xiaofu, Pan Shizhong, et al (Department of Endocrinology, The 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350005);The effect of the increase in blood cell volume on microangiopathy in diabetic patients[J];CHINESE JOURNAL OF DIABETES;2000-02
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