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《Hebei Medical Journal》 2010-14
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Effect of HO-1 protein on CD_(54) expression in mice with acute lung injury

ZHANG Jianwu, XING Zhiwei.Provincial Chest Hospital,Shijiazhuang 050041,China  
Objective To observe the effect of HO-1 protein on CD54 expression in mice with acute lung injury.Methods The models of mice with acute lung injury were established,and the expressions of HO-1 and CD54 protein were detected in the lung tissue of acute lung injury mice by Western Blot and flow cytometry.Results There was a significant difference in the expression of HO-1 between hemin+LPS group and control group(P0.05),and the expression of CD54 in LPS group was significantly higher than that of control group(P0.05).Conclusion HO-1 induction expression has a protective effect on acute lung injury in mice,which can reduce CD54 protein expression in lung tissue.
【Fund】: 河北省医学科学研究重点课题(编号:08038)
【CateGory Index】: R563.8
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