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《Hebei Medical Journal》 2010-18
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Clinical significance of the expression of EZH2 and P16 protein in thyroid papillary carcinoma

ZHU Weidong* ,WANG Xin* ,ZHANG Yibing. * Department of General Surgery,Tangshan People’s Hospital,Hebei, Tangshan 063001,China  
Objective To investigate the clinical significance of the expression of EZH2 and P16 protein in thyroid papillary carcinoma. Methods Immunohistochemical staining was used to determine the expression of ezh2 and P16 protein in 50 cases of thyroid papillary carcinoma and 20 cases of adenomas. Results The positive rate of expression of EZH2 in thyroid papillary carcinoma was significantly higher than that of adenomas tussue ( 48% vs 20%,P 0. 05) ,however,the positive rate of expression of P16 in thyroid papillary carcinoma was significantly lower than that of adenomas tussue ( 42. 0% vs 75. 0% ,P 0. 05) . The expression of EZH2 and P16 was closely correlated with metastasis and recurrence ( P 0. 05 ) ,however,there was no correlation with patients’age,sex,tumor size and clinical stage( P 0. 05) . Conclusion The expression of EZH2 and P16 may be involved in the pathogenesis and development of thyroid carcinoma,which is helpful to monitoring the progression and evaluating prognosis in patients with thyroid carcinoma.
【CateGory Index】: R736.11
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