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《Hebei Journal of Traditional Chinese Medicine》 2007-12
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Experimental study of the effect of acid Monkshood polysaccharide on the immunologic function in immunosuppressive mice

MIAO Zhihui,LIU Jingsheng,WANG Yanling,et al.Hebei Center For Disease Prevention and Control,Hebei,Shijiazhuang 050021  
Objective To observe the effect of Monkshood acid polysaccharide on immunologic function in immunosuppressive mice.Methods The acid Monkshood polysaccharide(AMP) was obtained by phytochemistry extraction.The immunosuppressive mice models were made by injecting cyclophosphamide intraperitoneally.The immunosuppressive mice were administrated by gavage and intraperitoneal injection with AMP.The thymus and spleen index,phagocytosis of macrophages,hemolysin,lymphocyte transforming rate,NK cell activity and peripheral-blood WBC were detected and compared with those of model mice to evaluate the effect of acid Monkshood polysaccharide on the humoral and cell immunological function in immunosuppressive mice.Results AMP could enhance the index of spleen and thymus of immunosuppressive mice,and increase the phagocytic activities of peritoneal-blood macrophage,the ability of antibody forming and lymphocyte transforming rate,and increase the activities of NK and the counts of WBC.There were significant differences between experimental groups and control group(P0.05 or P0.01).The effects of intraperitoneal injection was superior to those of gavage administration(P0.01).Conclusion AMP could increase humoral and cell immunity function of immunosuppressive mice,moreover,which could relieve the decrease of WBC caused by cyclophosphamide.The results showed that the effects of AMP would be influenced by different administration ways.AMP has broad development and application prospect in clinic.
【Fund】: 河北省卫生厅重点科研课题(编号:2004043)
【CateGory Index】: R285
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