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Effect of Dongxuexiao Jieduhuoxue decoction on endothelin in blood serum of rat with chronic atrophie gastritis

WANG Shujie, LIU Qiquan, QI Yuan, et al. Department of Traditional Chinese Medicine, Second Hospital Affiliated to Baotou Medical College, Neimenggu, Baotou 014030  
Objective To explore the mechanism of action of Dongxuexiao Jieduhuoxue decoction on chronic atrophie gastritis. Method Rat model with chronic atrophie gastritis were established by the synthetic method. Then the general state of health,gastric mucous membrane of the rats were observed in general. And the ET level of blood serum in rat was determined by Radioimmunoassay. Results The experimental study showed that Dongxuexiao Jieduhuoxue decoction can influence hormone secretion and strengthen the nourishment and defenses function of the gastr-mucosa through restrainting the release of ET. Conclusion Dongxuexiao Jieduhuoxue decoction has evident therapeutic action on chronic atrophie gastritis.
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