Treatment of refractory membranous nephropathy using Guiqishengjiangsan combined with Zhengqingfengtongning release tablets
GAO Junjie* ,YANG Hongqing,ZHUANG Kesheng,et al.* Department of Nephrology,Cangzhou Central Hospital in Hebei Province,Hebei,Cangzhou 061000
Objective To observe the clinical effect of refractory membranous nephropathy treated by Guiqishengjiangsan combined with Zhengqingfengtongning release tablets.Methods 46 patients with refractory membranous nephropathy were randomly divided into two control group and treatment group.Patients in control group(n = 23) were treated by cyclosporin a(CSA).23 cases in treatment group received Zhengqingfengtongning release tablets.Clinical effect,traditional Chinese medicine symptom score and the changes of 24 h urine protein,plasma albumin and hepatorenal function before and after treatment was observed in two groups.Results The total effective rate of clinical effect in treatment group(86.96%) was superior to that in control group(69.57%,P 0.05).Compared with those before treatment traditional Chinese medicine symptom score and 24 h urine protein after treatment were significantly decreased in two groups(P 0.05),plasma albumin was obviously increased(P 0.05).Decrease of traditional Chinese medicine symptom score and 24 h urine protein in treatment group was more obvious than that in control group after treatment,increase of plasma albumin was significant(P 0.05).Conclusion Guiqishengjiangsan combined with Zhengqingfengtongning release tablets is an effective therapy on refractory membranous nephropathy,the clinical effect and decreasing 24 h urine protein,increasing plasma protein and decreasing traditional Chinese medicine was superior to that in CSA treatment.
【CateGory Index】： R277.5