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《Hebei Journal of Traditional Chinese Medicine》 2017-06
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Clinical observation of Xianling-gubao capsules combined with Alendronate Sodium on system lupus erythematosus complicated with osteoporosis

ZENG Keqin;ZHOU Erye;WU Jian;Department of Rheumatology,the First Hospital Affiliated to Soochow University;  
Objective To observed the effects and security of Xianling-gubao capsules combined with alendronate sodium on the treatment of system lupus erythematosus( SLE) complicated with osteoporosis. Methods 60 SLE complicated with osteoporosis patients were randomly divided into two groups. The doses of glucocorticoid and immunosuppressive agent were stable in 2 groups,and all patients were routine supplemented with calcium and active vitamin D. 30 cases in control group were treated by alendronate sodium,30 cases in treatment group were treated by Xianling-gubao capsules on the basis of the control group. The clinical effects in two groups were evaluated after 24 weeks treatment. The bone mineral density T score and serum indexes including serum calcium,serum phosphate,serum alkaline phosphatase( ALP),N-mid osteocalcin( N-MID),tartrate-resistant acid phosphatase 5b( TRAP5b) and C-telopeptides of Type I collagen( CTX-I) were detected before and after treatment. Results The total effective rate in treatment group( 86. 67%) was superior to that in control group( 66. 67%,P 0. 05),thecurative effects intreatmen group was superior to control group. The bone mineral density T score after treatment were increased in two groups with statiscal difference( P 0. 05),and which in treatment group was higher than that in control group( P 0. 05). The ALP,TRAP5 b and CTX-I after treatment were obviously reduced in two groups,and the N-MID were increased( P 0. 05). The ALP and CTX-I after treatment in treatment group were lower than those in control group,and the N-MID was higher( P 0. 05). There was no statistical difference on serum calcium and serum phosphate between before and after treatment in two groups( P 0. 05). Conclusion Xianling-gubao capsules combined with alendronate sodium has exact effects on SLE complicated with osteoporosis.
【CateGory Index】: R580;R593.241
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