Preparation of an Enantioselective Ligand-exchange Membrane and its Application in Optical Resolution of DL-Amino Acids
Long,Yuan-De Huang,Tian-Bao (Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041)
A new optical resolution membrane, crosslinked polyvinyl alcohol membrane with L-proline as chiral ligand-exchange selector, was prepared and the examination of enantioselective permeability for DL-Tyr, DL-Phe and DL-Trp through the membrane was carried out. It was found that L-amino acids used experimentally were permeated predominately through the membrane. The mechanism of enantiomer resolution of racemic amino acids through the membrane would be similar to that of resolution by chiral ligand-exchange chromatography and the enantioselective absorption would play an important role in the enantioselective permeation of DL-amino acids via the membrane.