Improvement on the Synthesis of 1,4-Dihydropyridine Derivatives
WANG Jian-ping 1, DU Mei-ju2, FU Yong-ju3,WANG Jian-ge1, LI Ning1, ZHENG Ai-xia1(1. Department of Chemistry, Luoyang Normal University, Luoyang 471022, China; 2. Department of Chemistry, Shangqiu Normal University, Shangqiu 476000, China; 3. College of Chemical Engineering & Pharmaceutics, Henan University of Science and Technology, Luoyang 471003, China)
1,4-Dihydropyridine derivatives(1a~1d) were synthesized by improved Hantzsch reaction of aromatic aldehyde, ethyl acetoacetate and NH4HCO3 in a closed system filled with nitrogen gas under refluxing. The structures were confirmed by 1H NMR, IR and elemental analysis. The crystal structure of 1b was determined by XRD.