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《Hebei Medicine》 2012-10
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The Prognostic Value of the Kinetic Serum CA125 Detection in Patients with Epithelial Ovarian Cancer

WU Jing,LIN Shanna,ZHUO Jing(The Second Affiliated Hospital of Medical College of Shantou University, Guangdong Shantou 515041,China)  
Objective: To explore the prognostic value of the kinetic serum CA125 detection in patients with epithelial ovarian cancer.Method: The level of serum CA125 were examined in 42 patients with epithelial ovarian cancer primarily underwent operation in this hospital from Jan.2003 to Dec.2008,calculated the serum CA125 half-life and the normalized time,analyzed the median survival time and the mean time of recurrence.Result: The median survival times of patients(n=22) with CA125 half-life ≤20 days and those(n=20)20 days,were 38 months and 15 months(P0.05).Further,patients with serum CA125 normalized time ≤8 weeks(n=23) experienced a median survival of 37 months,compared to only 23 months for those(n=19)8 weeks(P0.05).Finally,the recurrent rate in patients with normalized time 8 weeks was higher than those ≤8 weeks.In contrast,the recurrent mean time was shorter than those ≤8 weeks.Conclusion: It is useful to predict treatment response and prognosis of epithelial ovarian cancer by serum CA125 decreased markers such as half-life and normalized time,the latter is more convenient.The increase of CA125 after treatment indicated recurrence.
【CateGory Index】: R737.31
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1 HE Wei 1, YE Zhi-mei 2, XIONG Guang-wu 1, YAO Zhen-wei 2, LIANG Zhi-qing 1 ( 1Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038; 2 Department of Obstetrics and Gynecology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400014, China);Relationship between the kinetics of serum CA125 and the prognosis of epithelial ovarian carcinoma patients[J];Acta Academiae Medicinae Militaris Tertiae;2004-22
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