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《CIESC Journal》 2011-07
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Study on p-hydroxybenzoic acid imprinted polymers with different functional monomers and their molecular recognition characteristics

WANG Cheli,ZHAO Xingli,FANG Lei,ZHANG Qi,ZHONG Jing,LI Liang(School of Pharmaceutical Engineering and Life Science,Changzhou University,Changzhou 213164,Jiangsu,China)  
Molecularly imprinted polymers(MIPs)using p-hydroxybenzoic acid(p-HB)as template,4-vinylpyridine(4-VP),acrylamide(AM)and α-methylacrylic acid(MAA)as functional monomers were prepared separately.First,the binding energy of p-HB with the above monomers is calculated by using the molecular mechanics method.The order of binding energy of p-HB with different monomers is 4-VPAMMAA.Second,the interaction strength between p-HB and different monomers is studied by UV analysis,which is in the same order(4-VPAMMAA).Third,the static adsorption experiments of the MIPs using 4-VP,AM or MAA as functional monomer show that the binding capacity order of these MIPs is also 4-VPAMMAA,the same with those from molecular mechanics calculation and UV analysis.The results demonstrate that 4-VP is the best among the three monomers,and molecular mechanics calculation and UV analysis can be used for the selection of a functional monomer for the synthesis of MIPs.Finally,the selectivity of the imprinted polymer made with 4-VP is also studied.The static adsorption distribution coefficient of p-HB is much higher than that of other analogs,and the separation factor between p-HB and o-HB is 1.4.
【Fund】: 江苏省“青蓝工程”资助项目(QLG02020002)~~
【CateGory Index】: O631.3
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