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《Hebei Chemical Engineering and Industry》 2010-03
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Screening of High FK 506-Producing Strain by Combined Mutation

WANG Xiu-qin,WANG Xiao-lei,JIANG Qin(National Engineering Research Center of Microbial Medicine,New Drug R & D Co.,Ltd of North China Pharmacentical Corp,Shijiazhuang 050015,China)  
Combined mutation was used to treat the original strain streptomyces tsukubaensis 08-6-9,a high FK 506-producing strain 08-9-81 was obtained,the FK 506 productivity of which was further improved by 73.6% than the original strain in shaking culture,it was successfully used in scaling up in 20 L bioreactor,which was significant in realistic production.
【CateGory Index】: Q933
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