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《Environmental Science》 2004-01
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Reproductive Toxicity and Functional Mechanism of the Environmental Hormone Butyl Benzyl Phthalate

LI Wen-lan1,JI Yu-bin2,YANG Yu-nan3,YANG Bo2 (1.College of Civil Environmental Engineering,Harbin University of Technology,Harbin 150090, China; 2. Postdoctoral Programme,Harbin University of Commerce, Harbin 150076, China; 3.Department of Enviromental Engineering, Beijing University of Aeronautics and Astronautics,Beijing 100083,China)  
Sustained toxicity of butylbenzyl phthalate in vivo of rat was evaluated at a dose of 1000,500 and 250 mg/kg for 6 weeks and 20 weeks. The results show that butylbenzyl phthalate induce a decrease incidence of rats' testicle (p less 0.01), epididymides and prostate (p less 0.05). And tumefaction of liver (p less 0.01) is found. Histopathologic change is observed on testicle , prostate (p less 0.05) and liver (p less 0.01). Especially butylbenzyl phthalate can induce atrophy and denaturalization of convoluted seminiferous tubute and decreasing of spermatogenic cell on all levels. Configuration of spermatogenic cell and Sertoli cell is markedly in disorder. Conjunctive configuration between cells disappeared. In serum the activity of γ-G (p less 0.01) and ALP (p less 0.05) and the level of testosterone (p less 0.01) are reduced. In opposition the activity of LDH (p less 0.01) and the level of FSH (p less 0.01) are increased. The alterations present hypotaxis of dose-effect and time-effect. Combining with the alteration of histopathology and sex hormone, it shows butylbenzyl phthalate's target cell is Sertoli cell and the chondriosome is its target. Butylbenzyl phthalate induces female rats accretion of uterus, slight inflammation of histopathology and decreasing of ALP's activity (p less 0.05). All the evidences adequately prove that sexual difference exists for animals' disturbance. Butylbenzyl phthalate is more harmful for male than female.
【Fund】: 国家教育部重点科研项目 ( 2 0 48);; 黑龙江省科学技术计划攻关项目 (GC0 2C2 0 9)
【CateGory Index】: X503
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