The prevention of Absorption of ~(58)Co from the gastrointestinal tract by sodium alginate and removal of ~(58)Co from the body by 811
Zhu Shou-peng Zhao Jing-yong Su Kun-yuanMo Qi-zhong Wang Guo-lin Lao Qin-hua Gao Xian-hua(Suzhou Medical College)
This paper describes the laboratory animal studies on the prevention of absorption of 58Co from the gastrointestinal tract. The results suggest that sodium alginate is effective in reducing the absorption of 58Co from the gastrointestinal tract. In the first 2 days after giving radioactive cobalt by gastrolavage and administration of sodium alginate, the faecal excretion of 58Co was increased evidently while the elimination from the urine was decreased. In the meantine, the chelating agents 811 and DTPA were tested for the abilities of removing 58Co from the body. Both 811 and DTPA effectively promoted the quick excretion of radioactive cobalt from the urine. However the side-effect of 811 was smaller than DTPA hence the treatment of 58Co intoxication in the body by 811 is favourable.