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《ACTA SCIENTIAE CIRCUMSTANTIAE》 2000-02
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Bioassay of estrogenic effect of dicofol using uterine weight method in mice

ZHAO Bingshun\+1,ZOU Jichao\+1,CHU Shaogang\+2,XU Xiaobai\+2,DU Kejiu\+2\ (1.State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100080;2.Laboratory of Environmental Analytical Chemistry & Ecological Toxic  
The estrogenic activity of dicofol locally produced was investigated using the uterine proliferation in mice as an endpoint after subcutaneous administration. The results showed that there was no marked effect on the increase of uterine weight after treatment with lower doses of dicofol,but as the dose increased up to 4?mg and 8?mg the uterine weight increased significantly. Compaing with those of estradiol and o,p′\|DDT,of which the uterotropic actions were well documented, the estrogenic effect of dicofol is weaker than the two compounds. These results demonstrated that the locally produced dicofol possesses estrogenic activity, and the in vivo bioassay used in this study provides a simple and effective approach to screen the estrogenic action of environmental chemicals.
【Fund】: 国家自然科学基金!项目 (2 96770 2 6)
【CateGory Index】: R994.6
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