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Effects of Cadmium on Secretion Function of Macrophage

Wu Jing,Zhang Lin,Cheng Xuemin,et al Department of Environmental Health,Shanghai Medical University,Shanghai 200032  
In order to reveal the mechanism of suppression on immune system induced by cadmium,the level of biological mediums of supernate of mouse peritoneal macrophage exposed to cadmium was determined The results showed that 5 μmol/L and 10 μmol/L cadmium could result in the levels of tumor necrosis factor α(TNF α)and nitric oxide(NO) decreased,whereas the level of prostaglandin E 2(PGE 2) increased The alteration of biological mediums might be responsible for immune suppression of cadmium,the results also provided experimental reference for screening the sensitive biomarker of population exposed to cadmium
【CateGory Index】: R114
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