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《JOURNAL OF ENVIRONMENT AND HEALTH》 2000-02
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Study on the Effects of Cadmium on Sperm Motility of Rats in Vitro

XU Li chun,WANG Shu yi,WANG Xin ru The Key Laboratory for Applied Toxicology,Nanjing Medical University,210029  
Objective]To study the direct effects of cadmium on sperm motility among rats [Methods]The effects of cadmium chloride on the motility of isolated sperms of rats were observed by computer assisted sperm analysis (CASA) system Observed sperms were isolated from the caudal epididymides of healthy adult male SD rats with diffusion method.The moving speeds (VCL,VSL,VAPand BCF) and moving pattens (STR and LIN) of sperms were measured by CASA after one hour and two hour exposure to cadmium chloride with different cadmium concentrations of 0 5,2 0,8 0 mg/L.[WT5”,6FZ][Results]All moving parameters of sperms revealed no significant differences after 1 hour exposure to testing concentrations of cadmium After two hour exposure to cadmium,every motility parameters of sperms treated by 0 5 mg/L cadmium still showed no significant diffrences compared with those of controls,but many motility parameters of sperms treated by 2 0 and 8 0 mg/L cadmium reduced significantly compared with those of controls[Conclusion]It indicated that cadmium could result in direct toxic effects on motility of sperms in caudal epididymides of rats
【Fund】: 国家自然科学基金资助项目! ( 396 40 0 0 6 )
【CateGory Index】: R114
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