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《Journal of Environment and Health》 2004-05
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Effects of B(a)P on T-AOC in Liver of Carassius auratus

ZHANG Chun,ling, HU Jun,feng, WANG Pi,wen, et al. Department of Occupational and Environmental Health, School of Public Health, Shandong University, Jinan, Shandong 250012, China  
Objective To study the effects of B(a)P on total antioxidative capacity(T,AOC) in liver of Carassius auratus, and explore the toxic mechanism of B(a)P in aquatic ecotoxicology. Methods Test groups of younger Carassius auratus were exposed to 3×10-4, 3×10-3, 3×10-2 and 3×10-1 mg/L B(a)P respectively. After exposure for 1 d, 3 d, 6 d and 12 d, T,AOC in the fish liver was determined respectively by colorimetry. Results After exposure for 6 d, the level of T,AOC in 3×10-1 mg/L dose group was significantly lower than that in the other groups (F=5.853, P0.01) and showed significant difference (t=7.114, P0.01) compared with 3×10-2 mg/L dose group. After exposure for 12 d, the level of T,AOC in 3×10-1 mg/L dose group decreased continuously and the level of T,AOC in 3×10-2 mg/L dose group was significantly decreased compared to the result obtained after exposure for 6 d (t=7.544, P0.01), the level of T,AOC in 3×10-2 mg/L dose group showed significant difference (t=9.728, P0.01) with 3×10-3 mg/L dose group. Significant negative correlation (r=-0.581, P0.01) between T,AOC and exposure dose was obtained after exposure for 12 d and the T,AOC level in 3×10-1 mg/L dose group decreased with the increasing of the exposure time(r=-0.830, P0.01). Conclusion B(a)P could damage the antioxidative system and decrease the resistant capacity of organisms to environmental toxicants.
【Fund】: 山东省科委基金资助项目(413774)
【CateGory Index】: R114
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