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《Journal of Environment and Health》 2007-03
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Effects of Cadmium on Uterotrophic Assay and Serum Sexual Hormones Level in Ovariectomized Rats

YANG Jin-song,ZHANG Wen-chang,CHEN Yu,et al.Department of Occupational and Environmental Health,School of Public Health,Fujian Medical University,Fuzhou,Fujian 350004,China  
Objective To study estrogenicity effect of cadmium with uterotrophic assay and to study the effect of cadmium on serum sexual hormones level in ovariectomized rats.Methods 40 ovariectomized SD rats aged 28 days were divided in to groups and treated respectively with cadmium by intraperitoneal injection at the doses of 0,0.12 and 1.2 mg/kg per day and estrogen of 0.03 mg/kg(positive control)per day for 3 consecutive days.Uteruses wet weight were measured and serum E2,P4,FSH,LH were determined.Results Compared with the control group,uteruses wet weight and organ coefficients significantly increased in high dose group and in estrogen group,there were differences(P0.05,P0.01),serum E2,P4 level were lower in high dose group but higher in estrogen group(P0.05 and P0.01 respectively),serum FSH,LH level were lower in low dose cadmium group(P0.01),serum LH level was higher in estrogen group(P0.01).Conclusion Under this condition,it is concluded that cadmium has estrogenicity effect,and shows endocrine disruptive effects by non-sexual gland tissue.
【Fund】: 福建省自然科学基金资助项目(F0210002)
【CateGory Index】: R114
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