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《Journal of Environment and Health》 2007-11
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Effects of Aluminium Exposure on α-CaMKⅡ in Hippocampus of Lactational Rats

HAO Feng-jin, XIE Xin, PIAO Xian-yu. Department of Biochemistry and Molecule Biology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, China  
Objective To explore the mechanism of aluminum-induced damage of learning and memory by studying the change of calcium-calmodulin-dependent protein kinase Ⅱ(CaMKⅡ) in the hippocampus of lactational rats. Methods Three groups of clean pregnant Wistar rats (120-200 g) were randomly divided into 3 groups. On the first day of parturition, the dams of two groups were given 0.3% and 0.6% AlCl3 through drinking water and terminated on the weaning day (21 days). Western blot was used to determine the content and activity of α-CaMKⅡ. Results The aluminum levels in the blood and brain of aluminum-treated rats were obviously higher than that in the control (P0.05) in a dose-dependent manner. The content and activity of α-CaMKⅡ in the hippocampus of aluminum exposed group decreased in a dose-dependent manner compared with the control group (P0.05). Conclusion Chronic aluminum exposure can decrease the activity and content of CaMKⅡ, which will play a most important role in the damage of learning and memory induced by aluminum.
【CateGory Index】: R114
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