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《Journal of Environment and Health》 2007-11
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Effects of Aluminium Exposure on α-CaMKⅡ in Hippocampus of Lactational Rats

HAO Feng-jin, XIE Xin, PIAO Xian-yu. Department of Biochemistry and Molecule Biology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, China  
Objective To explore the mechanism of aluminum-induced damage of learning and memory by studying the change of calcium-calmodulin-dependent protein kinase Ⅱ(CaMKⅡ) in the hippocampus of lactational rats. Methods Three groups of clean pregnant Wistar rats (120-200 g) were randomly divided into 3 groups. On the first day of parturition, the dams of two groups were given 0.3% and 0.6% AlCl3 through drinking water and terminated on the weaning day (21 days). Western blot was used to determine the content and activity of α-CaMKⅡ. Results The aluminum levels in the blood and brain of aluminum-treated rats were obviously higher than that in the control (P0.05) in a dose-dependent manner. The content and activity of α-CaMKⅡ in the hippocampus of aluminum exposed group decreased in a dose-dependent manner compared with the control group (P0.05). Conclusion Chronic aluminum exposure can decrease the activity and content of CaMKⅡ, which will play a most important role in the damage of learning and memory induced by aluminum.
【CateGory Index】: R114
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【References】
Chinese Journal Full-text Database 1 Hits
1 CUI Hui-hui,BAI Xiao-qin,LI Li,et al.The Cytology and Genetics Department of Shanxi Medical University,Taiyuan,Shanxi 030001,China;Genetic Toxicity of Aluminium Trichloride in Male Mice[J];Journal of Environment and Health;2009-01
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 SHEN Dong jie, ZHAO Xian ying (Third military medical university, Chongqing 400038, China);Aluminium and health[J];Foreign Medical Sciences-Section of Medgeography;2004-02
2 WANG Xinxing, WU ZhouyaJiangsu Family Planning Institute (Nanjing 210029);The relationship of the sperm nucleus DNA maturity to the semenparameters, and the fertilizing ability of the spermatozoa[J];;1998-02
3 YANG Yong-jian,HU Hao,LI Xiao-ping,WANG Qv-nan(Department of Occupational and Environmental Health,Anhui Medical University,Hefei 230032,China);DNA damage in mouse brain cells induced by subchronic exposure to aluminum chloride(AlCl_3)[J];Chinese Journal of Industrial Medicine;2005-03
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