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《Journal of Environment and Health》 2008-03
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Anti-aging Effect of Carnosine and T_3,T_4 and IGF-Ⅰ Level in Serum of Mice

LV Jin-fang,ZHANG Qin,NING Kang-jian,et al.Anhui Science and Technology University,Fengyang,Anhui 233100,China  
Objective To observe the effects of carnosine on anti-aging and T3,T4,IGF-Ⅰ level in the serum of mice.Methods Seventy-two mice were randomly divided into four groups,eighteen in each,the control,the aging mice model,vitamin E group and the carnosine group(mice were treated with carnosine through drinking water).The aging mice model was induced by D-galactose.T3,T4 and IGF-Ⅰlevel in the serum of mice were determined by RIA on the second and fourth weekend.Spontaneous activity index(frequency of spontaneous activity,standing time of spontaneous activity)and tolerance index(anti-fatigue,hypoxia tolerance)of mice were determined on the fourth weekend.Results The frequency of spontaneous activity of carnosine group was the highest than the other groups(P0.05).Standing time of spontaneous activity of carnosine group was significantly higher than that of aging mice model(P0.05).Anti-fatigue time in the carnosine group was almost the same as that in the control.The difference among the groups was not significant as for hypoxia tolerance time(P0.05).T4/T3 ratio of carnosine group was the lowest and the highest on the second and fourth weekend respectively,but the difference among groups was not significant(P0.05).IGF-Ⅰlevel in the serum in carnosine group increased significantly(P0.01).Conclusion Carnosine can increase ability of spontaneous activity of aging mice model and can keep IGF-Ⅰ in a higher level in the serum,these effects are considered to be related to anti-aging function.
【Fund】: 安徽省科技厅2005年重点科研基金资助项目(05023119);; 安徽省教育厅自然科学基金资助项目(2005kj320zc)
【CateGory Index】: R33
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