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《Journal of Environment and Health》 2008-08
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Effect of Cypermethrin and Deltamethrin on DNA Damage in Lymphocytes in Male Mice

TONG Jun-wang WA NG Ying. The Department of Prevention,North China Coal Medical University,Tangshan,Hebei 063000,China  
Objective To observe the damage of cypermethrin and dehamethrin to the male mouse lymphocyte DNA using comet assay.Methods Sixty-four male KM mice were divided randomly into eight groups:negative control group (peanut oil), cypermethrin low dose group(20 mg/kg),medium dose group(40 mg/kg),high dose group(80 mg/kg),deltamethrin low dose group (5 mg/kg),medium dose group(10 mg/kg),high dose group (20 mg/kg) and the positive control group (cyclophosphamide 40 mg/kg). The mice from positive control group were exposed by intraperitoneal injection,the others were exposed by gavage for 10 ml/kg. Peripheral blood of mice was extracted after exposed for seven days,a comet assay was made with peripheral blood lymphocytes. Results Before the contamination,no significant difference of mice body weight were observed among the groups (P0.05).After the contamination,the mice body weight of high dose group of cypermethrin and dehamethrin were lower than the negative control group (P0.05).Compared with the negative control group,significant difference of trailing rate and the trailing tail length were observed above of the high dose group of cypermethrin and deltamethrin and the positive group (P0.05),high dose group of cypermethrin and dehamethrin and the positive control group result in comet rates rising and comets cell migration increasing of peripheral blood lymphocytes of mice.Linear regression analysis showed the dose of cypermethrin and dehamethrin were positively related with the trailing rate and the trailing tail length (P0.05).Conclusion Cypermethrin and deltamethrin has a certain damage role to DNA of peripheral blood lymphocyte of male mice.
【CateGory Index】: R114
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